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Effects of thyroid status on clonidine-induced hypo-activity responses in the developing rat (1984)

Heal, D. J. ; Smith, S. D. L. ; Atterwill, C. K.

Springer

Journal of neural transmission 60 (1984), S. 295-302

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ISSN: 1435-1463

Keywords: Adrenoceptors ; clonidine hypoactivity ; developing brain ; thyroid hormone

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Clonidine-induced hypoactivity was studied in rats made neonatally hypo- and hyperthyroid (PTU or T4 administered between 1–27 days postnatally) as an indication of central presynapticα 2-adrenoceptor function. Paradoxically, at 28 days postnatally both treatments caused an increase in clonidine-hypoactivity compared with untreated control animals, which was not due to sex differences amongst littermates in the various groups. It is proposed that whereas the hyperthyroid neonate data perhaps reflect an enhancement of presynapticα 2 function similar to that seen in the adult rat brain, the result obtained for the hypothyroid neonates could perhaps be due to a retardation of the ontogeny of central noradrenergic neurones.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01249101

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Thermogravimetric analysis of poly(alkyl methacrylates) and poly(methylmethacrylate-g-dimethyl siloxane) graft copolymers (1994)

Smith, S. D. ; Long, T. E. ; Mcgrath, J. E.

Bognor Regis [u.a.] : Wiley-Blackwell

Journal of Polymer Science Part A: Polymer Chemistry 32 (1994), S. 1747-1753

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ISSN: 0887-624X

Keywords: poly(methyl methacrylate) ; polydimethylsiloxane ; thermogravimetric analysis (TGA) ; graft copolymers ; poly(alkyl methacrylates) ; Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: The thermal stabilities of various poly(alkyl methacrylate) homopolymers and poly(methyl methacrylate-g-dimethyl siloxane) (PMMA-g-PSX) graft copolymers have been determined by thermogravimetric analysis (TGA). As expected, the thermal stabilities of poly(alkyl methacrylates) were a function of the ester alkyl group, and polymerization mechanism. In particular, thermally labile linkages, which result from termination during free radical or nonliving polymerization mechanisms, decrease the ultimate thermal stabilities of the polymers. However, graft copolymers, which were prepared by the macromonomer technique with free radical initiators, exhibited enhanced thermal stability compared to homopolymer controls. A more complex free radical polymerization mechanism for the macromonomer modified polymerization may account for this result. © 1994 John Wiley & Sons, Inc.

Additional Material: 9 Ill.