ISSN:
1040-0397
Keywords:
Voltammetry
;
Metalloporphyrin
;
DNA
;
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
A series of metalloporphyrins (CuTMpyP, CuTMAP. CuTPPS, NiTMpyP, ZnTMpyP and CdTMpyP) reacting with DNA were compared. The interaction of metalloporphyrin with DNA shows different binding modes and electrochemical behavior when either the metal ion or porphyrin ligand is different. Due to electrostatical repulsion interaction between the anionic substitute group and a phosphate group on DNA molecular backbone, it is difficult for the anionic porphyrin to interact with DNA. The ability of cationic porphyrins to react with DNA depends on the size of the substitute group and the metal ion in the porphyrin plane center. Metalloporphyrin with or without axial ligand, which depends on the metal ion, results in outside binding or intercalating modes, and shows different interaction capability with DNA. The conditional binding constants of NiTMpyP, CuTMpyP and CuTMAP, which mainly show intercalating mode to DNA, were evaluated.
Additional Material:
9 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/elan.1140091709
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