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  • 1
    Electronic Resource
    Electronic Resource
    Clinical evaluation of the partition model for estimating radiation doses from yttrium-90 microspheres in the treatment of hepatic cancer (1997)
    Springer
    European journal of nuclear medicine 24 (1997), S. 293-298 
    Details
    ISSN: 1619-7089
    Keywords: Partition model ; Clinical evaluation ; Yttrium-90 microspheres ; Hepatic cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Radiation doses to the tumour and non-tumorous liver compartments from yttrium-90 microspheres in the treatment of hepatic cancer, as estimated by a partition model, have been verified by correlation with the actual doses measured with a beta probe at open surgery. The validity of the doses to the lungs, the tumour and non-tumorous liver compartment as estimated by the partition model was further evaluated in clinical settings. On the basis of the observation that one of three patients who received more than 30 Gy from a single treatment and one of two patients who received more than 50 Gy from multiple treatments developed radiation pneumonitis, it was deduced that an estimated lung dose 〈30 Gy from a single treatment and a cumulative lung dose 〈50 Gy from multiple treatments were probably the tolerance limits of the lungs. Three of five patients who received lung doses 〉30 Gy as estimated by the partition model and were predicted to develop radiation pneumonitis, did so despite the use of partial hepatic embolization to reduce the degree of lung shunting. Furthermore, a higher radiological response rate and prolonged survival were found in the group of patients who received higher tumour doses, as estimated by the partition model, than in the group with lower estimated tumour doses. Thus the radiation doses estimated by the partition model can be used to predict (a) complication rate, (b) response rate and (c) duration of survival in the same manner as the actual radiation doses measured with a beta probe at open surgery. The partition model has made selective internal radiation therapy using90Y microspheres safe and repeatable without laparotomy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728766
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  • 2
    Electronic Resource
    Electronic Resource
    Clinical evaluation of the partition model for estimating radiation doses from yttrium-90 microspheres in the treatment of hepatic cancer (1997)
    Springer
    European journal of nuclear medicine 24 (1997), S. 293-298 
    Details
    ISSN: 1619-7089
    Keywords: Key words: Partition model ; Clinical evaluation ; Yttrium-90 microspheres ; Hepatic cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Radiation doses to the tumour and non-tumorous liver compartments from yttrium-90 microspheres in the treatment of hepatic cancer, as estimated by a partition model, have been verified by correlation with the actual doses measured with a beta probe at open surgery. The validity of the doses to the lungs, the tumour and non-tumorous liver compartment as estimated by the partition model was further evaluated in clinical settings. On the basis of the observation that one of three patients who received more than 30 Gy from a single treatment and one of two patients who received more than 50 Gy from multiple treatments developed radiation pneumonitis, it was deduced that an estimated lung dose 〈30 Gy from a single treatment and a cumulative lung dose 〈50 Gy from multiple treatments were probably the tolerance limits of the lungs. Three of five patients who received lung doses 〉30 Gy as estimated by the partition model and were predicted to develop radiation pneumonitis, did so despite the use of partial hepatic embolization to reduce the degree of lung shunting. Furthermore, a higher radiological response rate and prolonged survival were found in the group of patients who received higher tumour doses, as estimated by the partition model, than in the group with lower estimated tumour doses. Thus the radiation doses estimated by the partition model can be used to predict (a) complication rate, (b) response rate and (c) duration of survival in the same manner as the actual radiation doses measured with a beta probe at open surgery. The partition model has made selective internal radiation therapy using 90Y microspheres safe and repeatable without laparotomy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728766
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  • 3
    Electronic Resource
    Electronic Resource
    Fluorescence depolarization studies of conformation changes in pyrene-butyryl-fumarase (1978)
    New York : Wiley-Blackwell
    Biopolymers 17 (1978), S. 2373-2384 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Measurements of fluorescence depolarization on fumarase labeled with the dye pyrene-butyryl were used to test for previously reported structural changes in this enzymes. These apparent conformation changes were of interest because they seemed to correlate with variation in catalytic activity provoked by changing temperature or pH, or by the presence of a competitive inhibitor. In the present studies, the bound dye pyrene-butyryl and the enzymes were investigated systematically to ensure that simple interpretation of fluorescence depolarization results would be meaningful. This analysis showed that carefully controlled experimental condition were necessary to eliminate a dye component with a short fluorescence lifetime and that it was essential to allow for small variations of lifetime with temperature. Contrary to the previous report, a constant rotational relaxation time of the magnitude expected for a nearly spherical molecule of fumarase was found. No changes were detectable by fluorescence depolarization in the size or shape of pyrene-butyryl-fumarase under the solution conditions tested that caused variation in enzyme activity.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.1978.360171007
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  • 4
    Electronic Resource
    Electronic Resource
    Novel curing systems for chlorosulfonated polyethylene (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 8 (1964), S. 337-354 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Polyfunctional alcohols, acyclic, cyclic, and heterocyclic imines, and organotin oxides have been studied as crosslinking agents for chlorosulfonated polyethylene. Mechanisms for the crosslinking reactions involving the sulfonyl chloride moiety have been proposed. Differences in curing activity have been correlated with structural modifications of the curing agents consistent with classical chemical reactions for nonpolymeric systems. Of the curing systems examined, the polyols provide nontoxic, low cost, safe-processing formulations offering excellent physical properties which have found use in practical commercial applications.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1964.070080121
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  • 5
    Electronic Resource
    Electronic Resource
    A general correlation of the flammability of natural and synthetic polymersPresented at the 3rd International Cellular Plastics Conference, The Society of the Plastics Industry, Montreal, September 27, 1972. (1974)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 18 (1974), S. 491-504 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The concept that flammability is fundamentally related to the potential thermal energy available per unit of volume of material emerged from attempts to correlate the effect of composition variables on the flammability of neoprene vulcanizates as measured by the oxygen index (O.I.) test. The origins of this test clearly show that it is a highly specific measure of flammability - the tendency of a composition to continue to burn once ignited - and that it is thermodynamically related to the heat of combustion of materials. This relationship is developed to a linear correlation which includes a wide variety of synthetic and natural materials and permits reasonable prediction of O.I. values from elemental analysis. Polymeric materials containing carbon and oxygen in atom ratios of less than 6 to 1 are more flammable than predicted. The effect of atmospheric temperature on O.I. can be predicted in relation to the O.I. value at normal temperature. This effect is shown to be independent of the composition of the material being tested. These two correlations permit the construction of a simple general map of flammability against which experimental data can be compared and judgments made with respect to the significant variables involved. There appears to be a significant relation between O.I. data, as viewed from these correlations, and the data of other flammability tests.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1974.070180215
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  • 6
    Electronic Resource
    Electronic Resource
    An in vitro and in vivo analysis of anodized tantalum capacitive electrodes: Corrosion response, physiology, and histology (1977)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 11 (1977), S. 637-656 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Oxidation-reduction reactions which can destroy high current-density metalstimulating electrodes are avoided when using capacitive electrodes. The results of in vitro and in vivo testing of anodized, high surface area, sintered tantalum electrodes are presented. The corrosion response of the electrodes is excellent; there is no evidence of dissolution of the electrode. A deposit forms on the surface of the electrodes, but has little effect on the voltage response to constant current stimulation. The physiological and histopathological results indicate the capacitive tantalum electrode to be the safest yet tested.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820110502
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  • 7
    Electronic Resource
    Electronic Resource
    An in vitro model for evaluating neural stimulating electrodes (1976)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 10 (1976), S. 907-928 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: A model for in vitro evaluation of materials for use as neural stimulation electrodes is developed. Critical areas of concern in developing an in vitro test model discussed include: selection of environment, choice of material, design of stimulating equipment, and analytical procedures used to evaluate materials response. A method of providing quantitative analysis of materials response to stimulation conditions is presented. Evaluation techniques involve the use of scanning electron microscopy, x-ray spectroscopy, atomic absorption spectrometry, and potentiographic and dielectric analysis of the test electrodes. A diagnostics matrix is presented which assigns a scale factor to quantify the relative corrosion response of the candidate materials. The corrosion response of Pt electrodes is evaluated in terms of scale factors assigned through use of the diagnostics matrix.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820100609
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  • 8
    Electronic Resource
    Electronic Resource
    Characteristics of microemulsion polymerized styrene with water-soluble versus oil-soluble initiators (1984)
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Chemistry Edition 22 (1984), S. 3967-3982 
    Details
    ISSN: 0360-6376
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The effect of oil-soluble versus water-soluble free-radical generators in the polymerization of styrene in oil-in-water (O/W) micromulsions were investigated by photon correlation spectroscopy. The microemulsions were formed by styrene, brine, sodium dodecyl sulfate (SDS), and pentanol. The polymerizations were carried out in two microemulsions that contained droplets differing by a factor of 2.4 in volume. Under the conditions of φ = 0.019 and NaCl/SDS 〉 2 the microemulsions were stable and the droplets were independent of one another. Both oil-soluble and water-soluble initiators produced polystyrene that contained fractions of two different sizes. In the case of the oil-soluble initiator the droplet size in the microemulsion seemed to be correlated to the size of the product whereas in the case of the water-soluble initiator, there seemed to be little relation.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1984.170221232
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  • 9
    Electronic Resource
    Electronic Resource
    Ultracentrifuge studies on the crystalline compound of trypsin and of soybean trypsin inhibitor (1950)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Polymer Science 5 (1950), S. 375-375 
    Details
    ISSN: 0022-3832
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1950.120050308
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  • 10
    Electronic Resource
    Electronic Resource
    On the interaction of the globulin, arachin, with various ionsPresented at the International Congress of Pure and Applied Chemistry, New York, September, 1951. (1951)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Polymer Science 7 (1951), S. 605-634 
    Details
    ISSN: 0022-3832
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Additional Material: 18 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1951.120070607
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