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  • Polymer and Materials Science  (3)
  • DSC  (1)
  • Iodophenylalanine  (1)
  • 1
    Digitale Medien
    Digitale Medien
    A combined differential scanning calorimeter-optical video microscope for crystallization studies (1997)
    Springer
    Journal of thermal analysis and calorimetry 49 (1997), S. 991-998 
    Details
    ISSN: 1572-8943
    Schlagwort(e): cryo-microscopy ; crystallization ; DSC ; ICE ; microscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract A simultaneous differential scanning calorimeter (DSC)-optical video microscope instrument has been developed. The instrument development included slight modifications to the sample head of a Perkin-Elmer DSC-7, along with the use of a CCD camera and magnifying lenses. The instrument permitted simultaneous following of optical and thermal events during isothermal and non-isothermal DSC experiments. The DSC curves were almost identical to those given by a standard DSC-7. The operational temperature range of the instrument is between −160 to 600°C. The capabilities of the DSC-video microscope are illustrated by examples of ice crystallization data in aqueous solutions of glycerol and dimethyl sulphoxide.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01996785
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  • 2
    Digitale Medien
    Digitale Medien
    Successful and unsuccessful approaches to imaging carcinoids: Comparison of a radiolabelled tryptophan hydroxylase inhibitor with a tracer of biogenic amine uptake and storage, and a somatostatin analogue (1996)
    Springer
    European journal of nuclear medicine 23 (1996), S. 131-140 
    Details
    ISSN: 1619-7089
    Schlagwort(e): Carcinoid ; Radionuclide imaging ; Phenylalanine ; Metaiodobenzylguanidine ; Pentetreotide ; Iodophenylalanine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract A mouse mastocytoma model was used to determine the biodistribution and tumour uptake of four radiopharmaceuticals developed to target the serotonin synthetic pathway in carcinoid tumours. Three of the compounds were competitive inhibitors of the rate-limiting enzyme of serotonin synthesis, tryptophan hydroxylase. Radiolabelled iodo-dl-phenylalanine (iodine-131 PIPA) was found to have the highest uptake and tumourto-liver ratio. Four patients with known carcinoid tumours were then injected with 0.5 mCi131I-PIPA and imaged at 1, 4, 24 and 48 h post-injection. The radiopharmaceutical, however, failed to localize in the known tumour sites. This result was in contrast to the authors' experience of131I- and123I-MIBG imaging of carcinoid tumours. Seven patients with known metastatic carcinoid tumours, two patients with symptoms of recurrence following tumour resection, one patient with completely resected disease, and two patients with a flushing syndrome of uncertain aetiology were studied with131I-MIBG. Three of the seven patients with known metastatic disease had positive131I-MIBG scans. Both patients with clinical evidence of recurrent disease had negative scans, as did the patient who was considered to have had complete resection of her primary tumour. The two patients with idiopathic flushing syndrome also had negative scans. Among seven patients imaged with123I-MIBG there were four true-negative scans and one falsenegative, the latter in a patient with biochemical and CT evidence of recurrence. In a seventh patient with distant metastases there was variable uptake in some of the lesions. Four patients were studied with indium-111 penetetreodide. Two patients with metastatic carcinoid disease had positive scans, although hepatic metastases were not seen in one. Another two with idiopathic flushing syndrome had normal studies. The literature suggests that up 50% of carcinoid tumour cases are detected with131I-MIBG, compared to a sensitivity of 87% reported with somatostatin receptor imaging using111In-pentetreotide. The experience with123I-MIBG is much less extensive. The mechanisms of carcinoid tumour localization for each of the three classes of radiotracers are discussed and contrasted to their varying sensitivities. The relative success of131I-MIBG and111In-pentetreotide relative to131I-PIPA may be related to the fact that131I-MIBG is actively taken up and stored by the enterochromaffin cells of the tumours and111In-pentetreotide binds to cell surface receptors, whereas131I-PIPA binds to tryptophan hydroxylase, which may be present in quantities too small to permit tumours to be imaged.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01731835
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  • 3
    Digitale Medien
    Digitale Medien
    Ion conductive poly(ethylene oxide-dimethyl siloxane) copolymers (1996)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 34 (1996), S. 3465-3470 
    Details
    ISSN: 0887-624X
    Schlagwort(e): poly(ethylene oxide-dimethyl siloxane) copolymers ; ionic conductive polymers ; polymer electrolyte ; ionic conductivity ; dimethyl dimethoxy/diethoxysilane ; polyethylene glycol ; Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: A series of poly(ethylene oxide-dimethyl siloxane) copolymers,  -  [SiMe2O(CH2CH2O)n]m  -  (n = 2, 3, 4, 5, 6.4, 8.7, 13.3), were synthesised by the reaction of polyethylene glycol with dimethyl dimethoxy/diethoxysilane. Corresponding ion-conductive polymers were prepared by complexing these copolymers with salts (sodium tetrafluoroborate or ammonium adipate). The highest conductivity of these systems at room temperature was 3 × 10-4 S cm-1 and 6 × 10-5 S cm-1, respectively. The glass transition temperature of these copolymers is reported and is seen to be dependent on the length of the ether units. The effects of siloxane content, salt concentration, and temperature on the conductivity are discussed. © 1996 John Wiley & Sons, Inc.
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
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  • 4
    Digitale Medien
    Digitale Medien
    23Na NMR in urethane cross-linked polyether solid polymer electrolytes (1994)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part B: Polymer Physics 32 (1994), S. 2077-2084 
    Details
    ISSN: 0887-6266
    Schlagwort(e): NMR ; polyether urethane polymer electrolytes ; sodium triflate ; Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Physik
    Notizen: Sodium triflate/polyether urethane polymer electrolytes ranging in concentration from 0.05 molal to 1.75 molal have been investigated via 23Na static solid-state NMR. Room temperature spectra and spin lattice relaxation times were consistent with a single narrow resonance indicating the presence of only mobile ionic species. The concentration and temperature dependence of relaxation times, chemical shifts, and linewidth have been investigated. The results suggest either a single species or rapid exchange between a number of species (even at temperatures below the glass transition temperature, Tg). The linewidth decreases with increasing concentration of ions and remains temperature independent below Tg. Below Tg a maximum quadrupolar interaction constant of 2 MHz is calculated. The addition of plasticizer to the polymer electrolyte causes significant chemical shift changes that depend on the solvent donicity of the plasticizer. The linewidth and T1 relaxation times also depend on the Tg of the plasticized systems. Previous 23Na NMR literature results are reviewed and qualitative models developed to account for the variation in results. © 1994 John Wiley & Sons, Inc.
    Zusätzliches Material: 4 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/polb.1994.090321214
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  • 5
    Digitale Medien
    Digitale Medien
    A water-soluble siloxane: Poly(ethylene glycol) comb polymer (1985)
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Letters Edition 23 (1985), S. 465-467 
    Details
    ISSN: 0360-6384
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/pol.1985.130230903
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