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  • 1
    Electronic Resource
    Electronic Resource
    Analysis of the intrathecal immune response in neuroborreliosis to a sonicate antigen and three recombinant antigens ofBorrelia burgdorferi sensu stricto (1998)
    Springer
    European journal of clinical microbiology & infectious diseases 17 (1998), S. 159-166 
    Details
    ISSN: 1435-4373
    Keywords: Borrelia burgdorferi ; Recombinant proteins ; Enzyme immunoassay ; Antibody index
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The intrathecal synthesis of borrelial-specific IgM- and IgG-antibodies was studied in 67 patients with neuroborreliosis and in 14 patients with neurosyphilis (controls). Antibody concentrations in serum and in the cerebrospinal fluid were determined by an enzyme immunoassay (EIA) using, as antigens, a sonicate ofBorrelia burgdorferi, the recombinant 14 kDa flagellin fragment, the outer surface protein C (22 kDa), and the high molecular mass protein p83 (83 kDa). In the sonicate EIA, IgG- and/or IgM-antibodies toBorrelia burgdorferi in serum were detected in all patients with neuroborreliosis and in 71% of patients with neurosyphilis. Intrathecal synthesis of borrelial-specific IgG- and/or IgM-antibodies was demonstrated in 82% of patients with neuroborreliosis and in 71% of patients with neurosyphilis. Immunoglobulin G- and/or IgM-antibodies in serum against any of the recombinant antigens were detected in 92% of patients with neuroborreliosis and in none of those with neurosyphilis. Intrathecal synthesis of IgG- and/or IgM-antibodies to individual recombinant antigens was demonstrated in 67% of patients with neuroborreliosis and in none of those with neurosyphilis. The sensitivity of the recombinant antigens in serum was almost equal to that of the sonicate EIA, whereas the recombinant antigens were clearly less sensitive in the estimation of the intrathecal specific immune response. It was concluded that in suspected cases of neuroborreliosis, the estimation of high specific antibodies in the recombinant EIA will be helpful in confirming the diagnosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01691111
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  • 2
    Electronic Resource
    Electronic Resource
    Analysis of the Intrathecal Immune Response in Neuroborreliosis to a Sonicate Antigen and Three Recombinant Antigens of Borrelia burgdorferi Sensu Stricto (1998)
    Springer
    European journal of clinical microbiology & infectious diseases 17 (1998), S. 159-166 
    Details
    ISSN: 1435-4373
    Keywords: Key words Borrelia burgdorferi ; Recombinant proteins ; Enzyme immunoassay ; Antibody index
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The intrathecal synthesis of borrelial-specific IgM- and IgG-antibodies was studied in 67 patients with neuroborreliosis and in 14 patients with neurosyphilis (controls). Antibody concentrations in serum and in the cerebrospinal fluid were determined by an enzyme immunoassay (EIA) using, as antigens, a sonicate of Borrelia burgdorferi, the recombinant 14 kDa flagellin fragment, the outer surface protein C (22 kDa), and the high molecular mass protein p83 (83 kDa). In the sonicate EIA, IgG- and/or IgM-antibodies to Borrelia burgdorferi in serum were detected in all patients with neuroborreliosis and in 71% of patients with neurosyphilis. Intrathecal synthesis of borrelial-specific IgG- and/or IgM-antibodies was demonstrated in 82% of patients with neuroborreliosis and in 71% of patients with neurosyphilis. Immunoglobulin G- and/or IgM-antibodies in serum against any of the recombinant antigens were detected in 92% of patients with neuroborreliosis and in none of those with neurosyphilis. Intrathecal synthesis of IgG- and/or IgM-antibodies to individual recombinant antigens was demonstrated in 67% of patients with neuroborreliosis and in none of those with neurosyphilis. The sensitivity of the recombinant antigens in serum was almost equal to that of the sonicate EIA, whereas the recombinant antigens were clearly less sensitive in the estimation of the intrathecal specific immune response. It was concluded that in suspected cases of neuroborreliosis, the estimation of high specific antibodies in the recombinant EIA will be helpful in confirming the diagnosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01691111
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  • 3
    Electronic Resource
    Electronic Resource
    Transverse NMR relaxation of water in wood (1979)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 23 (1979), S. 3147-3154 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The transverse NMR relaxation times of hydrogen nuclei of water absorbed in white spruce sapwood [Picea glauca (Meunch) Voss] were measured for moisture contents in the range from 5 to 176%. The spin echo amplitudes resulting from the Carr-Purcell sequence decay nonexponentially suggesting the possibility of at least two different relaxation times for water in wood. A simplified structural model of the wood-water mixture is used to estimate the rates of chemical exchange at room temperature of hydrogen nuclei between various sites in the system. The high-resolution NMR line shape is discussed briefly in terms of this proposed model.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1979.070231101
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  • 4
    Electronic Resource
    Electronic Resource
    Solid-phase synthesis of somatostatin and glucagon-selective analogs in gram quantities (1978)
    New York : Wiley-Blackwell
    Biopolymers 17 (1978), S. 1927-1938 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Somatostatin (SS) and two glucagon selective analogs [D-Cysl4]-SS and [D-Trp8, D-Cys14]-SS have been synthesized in gram quantities by the solid-phase procedure. A general modification of Monahan and Gilon's procedure for esterification of the first protected amino acid onto the chloromethylated resin as well as a general protocol for solid-phase peptide synthesis on Beckman 990 automatic synthesizer are described. A new general procedure for disulfide formation, which involves the adaptation of the “high-dilution” principle to the ferricyanide oxidation and the optimization of the sequence of purification steps as applied to somatostatin and its analogs, yields highly purified peptides (≥ 199% pure) as checked by reverse-phase high-pressure liquid chromatography - which is shown to be a highly sensitive, resolutive, and quantitative analytical tool for evaluation of the homogeneity of peptides.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.1978.360170809
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  • 5
    Electronic Resource
    Electronic Resource
    Über die Konstitution der Styrololigomeren aus der thermischen PolymerisationAuszugsweise vorgetragen im Makromolekularen Kolloquium in Freiburg i. Br. am 27. 2. 1970.Herrn Professor Dr. H. G. TRIESCHMANN zum 60. Geburtstag gewidmet (1970)
    Weinheim : Wiley-Blackwell
    Angewandte Makromolekulare Chemie 12 (1970), S. 25-41 
    Details
    ISSN: 0003-3146
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Saturated and unsaturated oligomers are formed by a side reaction during the thermal polymerization of styrene. MAYO has suggested that these oligomers are closely associated with the initiation step.Recently the structures of the dimer fraction were published by BROWN. By independent synthesis of the dimers we could confirm his results. The main components of the dimer fraction are trans- and cis-1.2-diphenylcyclobutane in a ratio of 3:1 ; also smaller amounts of 1.3-diphenylbutene-(3) and I-phenyltetralin were found.The aim of this work was to clarify the structures of the trimers. The trimer fraction contains about 30% of 1.3.5-triphenylhexene-(5), the structure of which was confirmed by independent synthesis. Furthermore we were able to show, that about 65% of the trimer fraction consists of the 4 optical inactive isomers of 1-phenyl-4-[1′-phenyläthyl-(1′)]-1.2.3.4.-tetrahydronaphthalene. Their structures were confirmed by dehydrogenation to 1-phenyl-4-[1′-phenyläthyl-(1′)]-naphthalene, which was identical to an independently synthesized sample.
    Notes: Bei der thermischen Polymerisation von Styrol entstehen in einer Nebenreaktion gesättigte und ungesättigte Oligomere, die nach MAYO in engem Zusammenhang mit der Startreaktion stehen.Durch unabhängige Synthese der Dimeren konnten wir die kürzlich von BROWN veröffentlichten Strukturen bestätigen. Hauptkomponenten der Dimerenfraktion sind trans- und cis-1.2-Diphenylcyclobutan im Verhältnis etwa 3:1; in kleineren Mengen wurden noch 1.3-Diphenylbuten-3 und 1-Phenyltetralin nachgewiesen.Hauptaufgabe dieser Arbeit war die Strukturaufklärung der trimeren Styrole. Das Auftreten von 1.3.5-Triphenylhexen-5 konnte durch Synthese gesichert werden; es ist zu etwa 30% in der Trimerenfraktion enthalten.Weiterhin konnten wir zeigen, daß etwa 65% der Trimerenfraktion aus den vier isomeren, optisch inaktiven 1-Phenyl-4-[1′-phenyläthyl-(1′)]-1.2.3.4.-tetrahydronaphthalinen bestehen. Die Struktur wurde durch Dehydrierung zum optisch inaktiven 1-Phenyl-4-[1′-phenyläthyl-(1′)]-naphthalin und dessen Vergleich mit einer unabhängig synthetisierten Probebewiesen.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/apmc.1970.050120103
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  • 6
    Electronic Resource
    Electronic Resource
    Synthesis of transparent fluorocarbon elastomers: Effect of crosslinker type and electron beam irradiation level on physical and mechanical behavior (1982)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 27 (1982), S. 957-968 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Saturated fluorocarbon elastomers are very resistant to chemical reactions, including those of a crosslinking nature. In order to study proper methods of preparing these materials, Viton GLT was mixed with various levels of trimethylol propane trimethacrylate, TMPTM, and triallyl isocyanurate, Diak #7. After molding, the materials were subjected to electron beam irradiation. The glass transition, rubbery modulus, viscoelastic behavior, and equilibrium swelling were used to characterize the materials as a function of crosslinker and irradiation level. In general, the modulus and gel fraction increased with both crosslinker content and irradiation level. Mixtures of both crosslinking monomers produced an unexpected synergism, yielding higher tensile strength, and earlier onset of gelation.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1982.070270315
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  • 7
    Electronic Resource
    Electronic Resource
    159. Zum Scale-up von Destillationskolonnen (1994)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 66 (1994), S. 1256-1256 
    Details
    ISSN: 0009-286X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cite.3306609160
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  • 8
    Electronic Resource
    Electronic Resource
    101. Zur Dimensionierung von Destillationskolonnen mit regellosen und strukturierten Packungen (1993)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 65 (1993), S. 1113-1114 
    Details
    ISSN: 0009-286X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cite.3306509103
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