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  • 1
    Digitale Medien
    Digitale Medien
    Different effects of early endotoxaemia on hepatic and small intestinal oxygenation in pigs (1996)
    Springer
    Intensive care medicine 22 (1996), S. 795-804 
    Details
    ISSN: 1432-1238
    Schlagwort(e): Key words Lipopolysaccharide ; Liver ; Small intestinal serosa and mucosa ; Tissue oxygen tension ; Acid ; base balance
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract   Objective:  Study on simultaneous O2 supply/uptake relationships in liver and gut during endotoxaemia, to determine whether signs of dysoxia develop uniformly in the splanchnic region. Design: Animal study to assess the early effects of endotoxaemia on oxygenation of both liver and small intestine. Interventions: Eight anaesthetized pigs received a continuous portal venous infusion of lipopolysaccharide (0.5 μg⋅kg-1⋅h-1) for 6 h. Systemic, pulmonary and splanchnic haemodynamics as well as systemic and splanchnic O2 supply/uptake relationships were determined. Results: There was a multiphasic haemodynamic response pattern characterized by an early (within the 1st h) and a subsequent more prolonged phase (between the 2nd and 6th h) of decreases and recovery of hepatic arterial, portal venous and superior mesenteric arterial blood flows (electromagnetic flow probes) and splanchnic O2 deliveries. Unrelated to perfusion pressure and O2 delivery, there were early and sustained decreases in ileal mucosal surface partial pressure of oxygen (PO2) (multiwire PO2 electrode) and pH (tonometry). This was not reflected by ileal serosal surface PO2, O2 uptake and arteriomesenteric venous pH and partial pressure of carbon dioxide (PCO2) gradients. There was little evidence of concomitant hepatic dysoxia as evaluated by surface PO2. Conclusions: The study demonstrates early and sustained regional (mucosa) intestinal hypoxia with little evidence of simultaneous hepatic dysoxia during initial endotoxaemia.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01709523
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  • 2
    Digitale Medien
    Digitale Medien
    Different effects of early endotoxaemia on hepatic and small intestinal oxygenation in pigs (1996)
    Springer
    Intensive care medicine 22 (1996), S. 795-804 
    Details
    ISSN: 1432-1238
    Schlagwort(e): Lipopolysaccharide ; Liver ; Small intestinal serosa and mucosa ; Tissue oxygen tension ; Acid-base balance
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Objective Study on simultaneous O2 supply/uptake relationships in liver and gut during endotoxaemia, to determine whether signs of dysoxia develop uniformly in the splanchnic region. Design Animal study to assess the early effects of endotoxaemia on oxygenation of both liver and small intestine. Interventions Eight anaesthetized pigs received a continuous portal venous infusion of lipopolysaccharide (0.5 μg·kg−1·h−1) for 6 h. Systemic, pulmonary and splanchnic haemodynamics as well as systemic and splanchnic O2 supply/uptake relationships were determined. Results There was a multiphasic haemodynamic response pattern characterized by an early (within the 1st h) and a subsequent more prolonged phase (between the 2nd and 6th h) of decreases and recovery of hepatic arterial, portal venous and superior mesenteric arterial blood flows (electromagnetic flow probes) and splanchnic O2 deliveries. Unrelated to perfusion pressure and O2 delivery, there were early and sustained decreases in ileal mucosal surface partial pressure of oxygen (PO2) (multiwire PO2 electrode) and pH (tonometry). This was not reflected by ileal serosal surface PO2, O2 uptake and arteriomesenteric venous pH and partial pressure of carbon dioxide (PCO2) gradients. There was little evidence of concomitant hepatic dysoxia as evaluated by surface PO2. Conclusions The study demonstrates early and sustained regional (mucosa) intestinal hypoxia with little evidence of simultaneous hepatic dysoxia during initial endotoxaemia.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01709523
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  • 3
    Digitale Medien
    Digitale Medien
    New polymer coated anion-exchange HPLC-phases: Immobilization of poly (2-hydroxy, 3N-ethylenediamino) butadiene on silica and alumina (1987)
    Springer
    Chromatographia 23 (1987), S. 435-441 
    Details
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Anion-exchange stationary phases ; Polymer coating ; Cross-linking
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary PHEB=POLY(2-hydroxy, 3N-ethylenediamino)butadiene has been synthesized. This unsaturated pre-polymer can be immobilized on different, preferably inorganic supports of suitable porosity such as silica or alumina by cross-linking. Weak anion-exchange phase are obtained. Such phases do not have the disadvantages of organic polymeric phases, regarding pressure stability and swelling by solvent influence. The ion-exchange capacity and the retentivity of IE-separations can deliberately be varied via the thickness of the cross-linked polymer layer. Alumina can also be coated with PHEB applying the same cross-linking procedure. Such phases exhibit an exceptional chemical stability even when operated with mobile phases at very high pH-values. Separations of excellent selectivity are achieved for inorganic anions, as well as with mixtures of aliphatic and aromatic free acids also including hydroxy- (mono- or poly)carboxylic acids.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02311821
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  • 4
    Digitale Medien
    Digitale Medien
    Polymer-coated cation-exchange stationary phases on the basis of silica (1987)
    Springer
    Chromatographia 23 (1987), S. 465-472 
    Details
    ISSN: 1612-1112
    Schlagwort(e): Cation-exchange LC ; Polymer coating ; Silica-based stationary phase
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary The procedure of polymer coating of preferably inorganic porous particle support materials for LC has been applied to the preparation of a new type of weak cationexchange phases. A special copolymer of butadiene and maleic acid could be immobilized on silica by cross-linking effected with radical starters such as peroxides or γ-radiation. The chromatographic properties of such materials proved to be excellent regarding efficiency, ion-exchange capacity and selectivity, as well as chemical stability also in comparison to other, commercially available, materials. Test measurements were successfully performed with ionic or ionizable inorganic and organic solutes over the entire applicable pH-range of the mobile phase which also contained organic modifiers. A special feature of the new type of cation-exchange phase is the minor contribution of hydrophobic (lipophilic) interaction to the retention mechanism besides the actual ion-exchange process.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02309412
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  • 5
    Digitale Medien
    Digitale Medien
    Chiral SFC-separations using polymer-coated open tubular fused silica columns. Comparison of enantiomeric selectivity in SFC and LC using the same stationary phase of the Pirkle type (1987)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 10 (1987), S. 665-667 
    Details
    ISSN: 0935-6304
    Schlagwort(e): Capillary SFC ; LC ; Chiral stationary phases ; Enantiomeric separations ; Polymer coating ; Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jhrc.1240101209
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  • 6
    Digitale Medien
    Digitale Medien
    HPLC-separation of enantiomers using quinine, covalently bonded to silica as stationary phase (1988)
    Springer
    Chromatographia 25 (1988), S. 265-271 
    Details
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Chiral phases ; Polymer coating ; Quinine substituted polysiloxanes
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary Stationary phases for chiral separations have been synthesized by chemical modification of porous small particle silica using new procedures of fixation of the chiral moiety. So called pre-polymers of the methylpolysiloxane polysiloxane type are immobilized on silica surfaces by different procedures. These pre-polymers are substituted by chiral groups. Their synthesis is done externally i.e. not in-situ on the support surface. The immobilization on the silica surface is achieved by crosslinking and/or by chemical bonding. Anchor groups within the pre-polymer (e.g. SiH) as well as on the silica surface (SiOH) give rise to the chemical bonding therewith. Chiral phases with quinine as the chiral moiety were obtained which show high separation efficiency as well as chemical stability, in addition to the enantiomeric selectivity required for the separation of certain types of aliphatic and aromatic alcohols.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02324699
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  • 7
    Digitale Medien
    Digitale Medien
    Chiral stationary phases for LC and SFC obtained by “Polymer coating” (1988)
    Springer
    Chromatographia 26 (1988), S. 19-28 
    Details
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Chiral LC and SFC phases ; Polymer coating ; Chemical bonding ; Polysiloxane pre-polymers
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary Chirally substituted Si−H-containing polysiloxanes were synthesized, which can be immobilized on small particle silica gel as well as on the smooth surfaces of fused silica capillaries. Immobilization is achieved either by crosslinking or by chemical bonding to the surfaces via silanol groups; both reactions can only be performed by addition of H2PtCl6, which acts as catalyst for hydrosilylation and as stoichiometric reagent for crosslinking. Chiral substituents of systematically varied chemical structure were introduced into the polysiloxanes by hydrosilylation. The mechanism of immobilization was investigated by spectroscopic methods, notably29Si-NMR. Homogenous stationary-phase coatings of variable film thickness and corresponding retentivity can easily be achieved. The enantioselectivity of the phase systems was characterized in dependency on the chemical structure of the chiral selectors attached to the polysiloxane chain of the chiral stationary phases and also in terms of the functional groups introduced into the solutes by derivatisation.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02268119
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