ISSN:
1432-2307
Keywords:
Sinonasal non-Hodgkin's lymphomas
;
Epstein-Barr virus infection
;
Polymerase chain reaction
;
In situ hybridization
;
Late membrane protein
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Sinonasal non-Hodgkin's lymphomas (SNHLs) of B- or T-cell immunophenotype have been associated with Epstein-Barr virus (EBV) infection of neoplastic lymphoid tissue. Nine SNHLs were investigated using immunohistochemistry, the polymerase chain reaction (PCR) for EBV genome and in situ hybridization (ISH) for EBV encoded RNAs (EBER), immunoglobulin (CI-gHR) and clonal T-cell receptor (CTCβR) gene rearrangements. Eight cases were diagnosed as peripheral pleomorphic T-cell lymphomas (pPTCL). PCR showed the presence of EBV genome in eight cases; ISH for EBER led to the detection of positive cells in five cases. Late membrane protein (LMP) immunostaining was observed in three cases. No EBV positivity has been detected in control cases. The frequent association with EBV infection in the cases illustrated confirms the previous suggestions that EBV may have a role in the genesis of lymphomas of the sinonasal region.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00230347
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