ISSN:
1573-3904
Keywords:
Peptide
;
Secondary structure
;
Raman
;
CD
;
Potassium-channel toxin
;
Sea anemone
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary Sea anemones possess small K-channel-blocking peptides about the same size as the scorpion K-channel toxins. We have estimated the secondary structure content (33% helix, 26% β-sheet) of one of these toxins, ShK toxin, using CD, Raman, and FTIR spectroscopy. A hypothetical 3D structure of the peptide core has been constructed using secondary structure and disulfide-linkage constraints; a single helical segment running from Ala14 through Leu25 is predicted.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00126735
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