ISSN:
1432-1076
Keywords:
Congenital adrenal hyperplasia
;
21-Hydroxylase deficiency
;
Prenatal diagnosis and treatment
;
Dexamethasone
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract A mother at risk for 21-hydroxylase deficiency was treated with oral dexamethasone (0.5 mg 12 hourly) from early pregnancy, in an attempt to prevent in utero virilization in case of a female fetus. Fetal karyotype was 46,XX, and because of a possible intra HLA recombination, treatment was continued to term. The newborn had a modest virilization and hormonal studies confirmed the diagnosis of congenital adrenal hyperplasia (CAH). This observation and review of the literature suggest that efficient prenatal treatment of CAH requires a higher and more frequent dosage of dexamethasone.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02106280
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