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  • Oestradiol  (3)
  • Prostate  (2)
  • 1
    Digitale Medien
    Digitale Medien
    Dose/response study of the effects of oestrogens on tumour growth and morphology in the Dunning R3327 prostatic adenocarcinoma (1992)
    Springer
    Journal of cancer research and clinical oncology 118 (1992), S. 30-34 
    Details
    ISSN: 1432-1335
    Schlagwort(e): Morphometry ; Oestradiol ; R3327 prostatic adenocarcinoma ; Testosterone
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The present study was undertaken to investigate to what extent the oestrogen-induced effects on growth and morphology of the Dunning R3327 rat prostatic adenocarcinoma are dose-dependent. Castrated and testosterone-supplemented rats were used in order to study effects of increasing doses of oestrogens on the tumour. It was found that the lowest dose of oestradiol-17β that reduced the overall growth, the volume density of the epithelium and epithelial cell area in Dunning R3327 prostatic tumours is 10 μg given as daily injections. Higher oestrogen doses (50 μg, 200 μg, and 500 μg), in addition to reducing the volume of tumour epithelium, also induced an increase of the volume density of tumour stroma. The area of stroma cell nuclei was increased by 50 μg and 200 μg oestradiol-17β. These observation, may indicate that the lowest effective oestrogen dose is different in the epithelium and stroma of Dunning tumours and that large doses of oestrogen stimulate the stromal compartment. This stimulatory effect did not influence the inhibitory effects seen on the overall growth of the tumour and on the tumor epithelium.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01192308
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  • 2
    Digitale Medien
    Digitale Medien
    Transient ischemia induces apoptosis in the ventral prostate of the rat (1999)
    Springer
    Urological research 27 (1999), S. 174-179 
    Details
    ISSN: 1434-0879
    Schlagwort(e): Key words Apoptosis ; Ischemia-reperfusion ; Blood flow ; Ischemia ; Prostate ; Rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The mechanisms involved in the castration-induced involution of the ventral prostate (VP) are not fully understood. It was recently reported that castration decreases blood flow in the VP in rats and that this occurs before the apoptotic involution of the organ. However, it is unknown whether a decrease in blood flow may trigger apoptosis in the VP, and this was therefore examined in this study. The right iliac artery was clamped for 1 h in adult male rats. After 24 h of reperfusion, the VPs were frozen or fixed. In situ end-labeling (ISEL) was used to identify apoptotic cells, and testosterone repressed prostatic message-2 (TRPM-2) was measured. Proliferating cell nuclear antigen (PCNA) immunohistochemistry was used to identify proliferating cells. Clamping the right iliac artery reduced blood flow in the right VP to 0.17 of that in the contralateral lobe. This relative ischemia resulted in a threefold increase in the volume density of apoptotic epithelial cells on the treated side, but left cell proliferation unaffected. Testosterone substitution did not change this pattern. This study suggests that a transient period of relative ischemia may induce apoptosis in the rat ventral prostate. This may be of importance for the understanding of castration-induced prostatic involution.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002400050106
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  • 3
    Digitale Medien
    Digitale Medien
    Blood flow in the duning R3327H rat prostatic adenocarcinoma; effects of oestradiol and testosterone (1986)
    Springer
    Urological research 14 (1986), S. 113-117 
    Details
    ISSN: 1434-0879
    Schlagwort(e): R3327H prostatic carcinoma ; Blood supply ; Testosterone ; Oestradiol
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Copenhagen x Fischer F1 rats were implanted with Dunning R3327H prostatic adenocarcinoma and studied over a period of three weeks. The tumour volumes in intact and testosterone supplemented castrated rats showed parallel increases. After castration alone the tumour volumes decreased. Treatment of castrates with oestradiol and testosterone combined produced an arrest of tumour growth, suggesting that oestradiol had a direct inhibitory effect on tumour growth. Blood flow in tumours was measured using the microsphere technique. In intact rats, tumour blood flow per unit of weight decreased with increasing weight of tumours and blood flow in peripheral parts was higher than in central parts of large tumours. Oestradiol in combination with testosterone increased tumour blood flow.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00257897
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  • 4
    Digitale Medien
    Digitale Medien
    Decrement of blood flow precedes the involution of the ventral prostate in the rat after castration (1997)
    Springer
    Urological research 25 (1997), S. 309-314 
    Details
    ISSN: 1434-0879
    Schlagwort(e): Prostate ; Castration ; Apoptosis ; Blood flow ; Radioactive microspheres ; Androgen receptors
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Blood flow to the rat ventral prostate (VP), dorsolateral prostate (DP), and Dunning R3327 prostatic tumors was measured at different times up to 7 days after castration, using the microsphere method. In the VP organ weight was decreased from day 3 onwards. Blood flow was, however, already significantly decreased from day 1. The reduced blood flow in VP in 1–3 and 7-day castrated animals could be reversed by testosterone treatment. Organ weight was slightly decreased but blood flow was unaffected by castration in DP. Castration left Dunning tumor volume and blood flow unaffected. Using immunohistochemistry, androgen receptors were observed in epithelial and stromal cells in VP, DP and Dunning tumors, but not in blood vessels. Castration is known to induce apoptosis in the VP, but not in the DP or in Dunning tumors. This suggests that a reduction in blood flow might be an important component for the castration-induced involution and apoptosis in prostatic tissue. The reason why castration reduces blood flow only in the VP, and not in the DP or Dunning tumor is unknown.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01294656
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  • 5
    Digitale Medien
    Digitale Medien
    Direct effects of oestradiol on growth and morphology of the dunning R3327H prostatic carcinoma (1987)
    Springer
    Urological research 15 (1987), S. 169-172 
    Details
    ISSN: 1434-0879
    Schlagwort(e): Morphometry ; Oestradiol ; R3327H prostatic carcinoma ; Testosterone
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Male Copenhagen x Fischer F1 rats were implanted with Dunning R3327H prostatic carcinoma, castrated when the tumours became palpable and were then treated with testosterone, testosterone in combination with oestradiol or oestradiol alone for four weeks. Treatment with oestradiol produced the smallest tumours. The testosteronestimulated growth of tumours was inhibited by oestradiol. The adenocarcinoma was moderately to well-differentiated. Morphometric analysis of the composition of the tumours showed that oestradiol stimulated tumour stroma and inhibited glandular epithelium. These effects were produced concomitantly with decreased overall tumour growth. Testosterone stimulated all cell types of the tumour.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00254431
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