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Digitale Medien

Recombinant human protein C, protein S and thrombomodulin as antithrombotics (1994)

Yan, S. Betty ; Grinnell, Brian W.

Springer

Perspectives in drug discovery and design 1 (1994), S. 503-520

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Details

ISSN: 1573-9023

Schlagwort(e): Antithrombotic proteins ; Protein C ; Protein S ; Thrombomodulin ; Recombinant proteins

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie

Notizen: Summary Over the last 10 years, much has been learned about the human protein C anticoagulation system, a key pathway in maintaining blood in a fluid state in vivo. Three major glycoproteins, namely protein C, protein S and thrombomodulin, are involved in this pathway. The aim of this article is to discuss therapeutic potentials and issues and challenges for developing recombinant protein C, protein S and soluble thrombomodulin as novel antithrombotics. We also briefly discuss other drug design strategies that may be employed in modulating the activity of the protein C anticoagulant pathway under pathological conditions.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF02171862

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