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  • 1
    Electronic Resource
    Electronic Resource
    Role of protein phosphorylation in regulation of brainL-glutamate decarboxylase activity (1994)
    Springer
    Journal of biomedical science 1 (1994), S. 237-244 
    Details
    ISSN: 1423-0127
    Keywords: γ-Aminobutyric acid ; L-glutamate decarboxylase ; Protein phosphorylation ; Neurotransmitter synthesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract In the brain, the γ-aminobutyric acid (GABA) level is primarily controlled by the activity of its synthesizing enzyme,L-glutamate decarboxylase (GAD). At present, mechanisms responsible for regulation of GAD activity remain largely unknown. Here we report that GAD activity is inhibited by conditions favoring protein phosphorylation, and this inhibition can be reversed by phosphatase treatment. Furthermore, this inhibition appears to result from the suppression of a Ca2+-dependent phosphatase. Phosphorylation of GAD is demonstrated by direct incorporation of32P into the GAD protein. These results suggest that GAD activity in the brain is inhibited by phosphorylation and activated by dephosphorylation. A model for regulation of GABA synthesis related to neuronal excitation is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02253308
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Computational limit analysis of rigid-plastic bodies in plane strain (1993)
    Springer
    Acta mechanica solida Sinica 6 (1993), S. 341-348 
    Details
    ISSN: 0894-9166
    Keywords: limit analysis ; mathematical programming ; finite element method
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract This paper deals with the computational methods for limit analysis of plane strain problems. The finite element mathematical programming formula (FE-MPF) for determining the upper bound load multiplier established by the authors earlier is adopted and modified for plane strain problems. The penalty method is used to impose the incompressibility constraint. The FE-MPF is solved by a direct iteration procedure without the need of a searching process. This algorithm is not sensitive to the volumetric locking effect. And it can be easily extended to the limit analysis of three dimensional problems. The results of numerical examples are satisfactory and show the stable convergency of the present algorithm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02208020
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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