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  • 1
    Electronic Resource
    Electronic Resource
    Zur Penetrationskinetik von Dehydroepiandrosteron durch die Erythrocytenmembran (1981)
    Springer
    Archives of dermatological research 270 (1981), S. 49-55 
    Details
    ISSN: 1432-069X
    Keywords: Psoriasis ; Dehydroepiandrosterone ; Penetration kinetics ; Erythrocytes ; Psoriasis ; Dehydroepiandrosteron ; Penetrationskinetik ; Erythrocyten
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei zehn Kranken mit Psoriasis vulgaris und zehn Kontroll-personen wurde die Penetrationskinetik von freiem Dehydroepiandrosteron (DHEA) durch die Erythrocytenmembran und der Metabolismus des penetrierten DHEA untersucht. Entsprechend früheren Befunden ist die Penetration des DHEA bei Psoriatikern erniedrigt und der intraerythrocytäre Stoffwechsel zugunsten einer verstärkten Reduktion dieses Steroids verschoben. Bei Psoriatikern und Kontrollpersonen ergab sich weiterhin eine lineare Abhängigkeit der Penetration von DHEA in den Erythrocyten von der DHEA-Konzentration im Inkubationsmedium. Dieser Befund weist am ehesten auf eine passive Diffusion dieses Steroids durch die Zellmenbran hin.
    Notes: Summary In ten patients with psorasis and ten controls the penetration kinetics of free dehydroepiandrosterone (DHEA) through the erythrocyte membrane and the metabolism of penetrated DHEA was studied. Corresponding to former findings in psoriatics the penetration of DHEA is decreased and the metabolism in the erythrocyte is shifted to an increased reduction of DHEA. Furthermore, in psoriatics and controls there was a positive correlation between the DHEA penetration through the erythrocyte membrane and the DHEA concentration outside the cell. These data point to a passive diffusion of DHEA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00417149
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Radioimmunologische Bestimmung von Dehydroepiandrosteron und 5-Androsten-3ß,17ß-diol im Plasma von Psoriatikern und Kontrollpersonen (1979)
    Springer
    Archives of dermatological research 266 (1979), S. 181-185 
    Details
    ISSN: 1432-069X
    Keywords: Radioimmunoassay ; Dehydroepiandrosterone ; Androstene-diol ; Psoriasis ; Radioimmunologische Bestimmung ; Dehydroepiandrosteron ; Androstendiol ; Psoriasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Mittels radioimmunologischer Bestimmungsverfahren wurden die Steroide Dehydroepiandrosteron und 5-Androsten-3ß,17ß-diol im Plasma von Psoriatikern und Kontrollpersonen bestimmt. Entsprechend den bereits früher mit photometrischen Methoden erhobenen Befunden war bei den Psoriatikern der Plasma-Spiegel des Dehydroepiandrosterons erniedrigt und der des Androstendiols erhöht.
    Notes: Summary In the plasma of psoriatics and controls the steroids dehydroepiandrosterone and 5-androstene-3ß,17ß-diol were determined by radioimmunoassay. Corresponding earlier findings obtained by photometric methods in psoriatics the plasma level of dehydroepiandrosterone is increased and that of androstenediol is decreased.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00694627
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Augmented glucose-6-phosphate dehydrogenase activity and normal penetration and metabolism of dehydroepiandrosterone in mononuclear leukocytes in psoriasis (1986)
    Springer
    Archives of dermatological research 278 (1986), S. 393-397 
    Details
    ISSN: 1432-069X
    Keywords: Glucose-6-phosphate dehydrogenase ; Dehydroepiandrosterone ; Mononuclear leukocytes ; Psoriasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The aim of the study was to determine a biochemical basis for the augmented oxidative metabolism found in mononuclear leukocytes (MNL) of patients with active psoriasis. Dehydroepiandrosterone (DHEA) is known to inhibit glucose-6-phosphate dehydrogenase (G-6-PDH). We determined the activity of G-6-PDH as well as the penetration and metabolism of DHEA — diminished plasma concentrations of which have been found in psoriatics previously — in 16 patients with active psoriasis and 16 controls. MNL in patients with psoriasis possessed 52% more (p〈0.05) G-6-PDH activity, based on cell number, and 34% more (p〈0.05) activity, based on soluble protein. No difference in DHEA penetration and metabolism in MNL was found between psoriatics and controls, in contrast with previous findings of reduced penetration and increased reduction in erythrocytes of psoriatics. We conclude that the enhanced G-6-PDH activity in MNL of patients with active psoriasis is not due to altered DHEA penetration or metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00418169
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    Paper (German National Licenses)
    Fulltext
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