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  • ROSETTA  (2)
  • Rat Folic Acid Reductase  (2)
  • 1
    Digitale Medien
    Digitale Medien
    Rat folic acid reductase activity during the perinatal period, in newborns, and after trimethoprim administration (1972)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 274 (1972), S. 229-237 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Rat Folic Acid Reductase ; Pregnancy ; Fetus ; Newborns ; Trimethoprim
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The folic acid reductase activity in various organs of adult rats was studied in comparison to pregnant females (20th day of gestation) and fetal rats. The enzyme activities in the tissues of pregnant rats were in general about 30% higher than in normal adults. Fetal rats also possess the ability to catalyze the reduction of dihydrofolic acid, but it is evident that the liver and kidney have a considerably reduced capacity to form tetrahydrofolate. The folic acid reductase activity in liver and kidney rises for 10 days after birth and then declines to normal enzyme levels by the 4th week of life. Further studies concerning the interaction between trimethoprim and folic acid reductase in adult rats demonstrate that an oral dose of 5 or 50 mg/kg results in about a 30% increase of folic acid reductase activity in liver and kidney. The experiments suggest that there is a stimulation of enzyme synthesis following trimethoprim administration; because, the trimethoprim induced increase of the reductase activity is blocked by the administration of either puromycin or actinomycin D.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00501932
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  • 2
    Digitale Medien
    Digitale Medien
    Inhibition of rat folic acid reductase activity by trimethoprim during the later stages of gestation (1973)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 278 (1973), S. 227-230 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Trimethoprim ; Rat Folic Acid Reductase ; Pregnancy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The increased level of folic acid reductase activity in rats during the perinatal period is inhibited following the oral administration of 5 or 50 mg/kg Trimethoprim. When the enzyme activity was tested in vitro, the highest sensitivity to the antimetabolite was displayed by the liver reductase isolated from rats the 20th day of pregnancy, the lowest was observed in the foetal liver extract. It is proposed that the stimulated reductase activity during the pregnancy is caused by a newly synthesized, Trimethoprim-sensitive enzyme form. The results of the in vitro experiments could contribute to the suggested hypothesis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00500653
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  • 3
    Digitale Medien
    Digitale Medien
    Rosetta Goes to Comet Wirtanen (1999)
    Springer
    Space science reviews 90 (1999), S. 313-319 
    Details
    ISSN: 1572-9672
    Schlagwort(e): ROSETTA
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract The International Rosetta Mission, approved by the Science Programme Committee of the European Space Agency as the Planetary Cornerstone Mission in ESA's long-term programme Horizon 2000, will rendezvous in 2011 with Comet 46P/Wirtanen close to its aphelion and will study the nucleus and the evolution of the coma for almost two years until it reaches perihelion. In addition to the investigations performed by the scientific instruments on board the orbiter, a Surface Science Package (Rosetta Lander) will be deployed onto the surface of the nucleus early during the near-nucleus study phase. On its way to Comet 46P/Wirtanen, Rosetta will fly by and study the two asteroids 4979 Otawara and 140 Siwa.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1005231006010
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  • 4
    Digitale Medien
    Digitale Medien
    Coma Composition and Evolution of Rosetta Target Comet 46P/Wirtanen (1999)
    Springer
    Space science reviews 90 (1999), S. 321-328 
    Details
    ISSN: 1572-9672
    Schlagwort(e): ROSETTA ; Space Mission Target Comets
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract Comet 46P/Wirtanen is the target comet of the ROSETTA mission. Here, we give an overview of the information currently available on this comet from remote-sensing observations. Main emphasis is put on the description of the coma in terms of morphology, composition and evolution. We also summarize the current knowledge of the basic properties of the nucleus, in particular its size and rotational properties.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1005235122848
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