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  • Rabbit  (2)
  • 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Insulin inhibits lipolytic activity and degradation of β-lipotropin in rabbit adipose tissue
    Amsterdam : Elsevier
    Regulatory Peptides 29 (1990), S. 257-266 
    Details
    ISSN: 0167-0115
    Keywords: Adipose tissue ; Insulin ; Lipolytic activity ; Rabbit
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-0115(90)90088-E
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Untersuchungen über biologische Wirkungen eines lipolytisch wirksamen Peptids aus Schweinehypophysen (Fraktion H) (1969)
    Springer
    Clinical and experimental medicine 149 (1969), S. 139-144 
    Details
    ISSN: 1591-9528
    Keywords: Fraction H ; Enzymeactivities ; Liver ; Adipose ; Rabbit ; Fraktion H ; Enzymaktivitäten ; Leber ; Fettgewebe ; Kaninchen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 2 Std nach Injektion von 500 μg Fraktion H wurden bei Kaninchen in Fettgewebe und Leber neun Schlüsselenzyme untersucht und mit den Befunden bei Kontrolltieren verglichen. Die signifikante Aktivitätsabnahme von Glucose-6-Phosphathehydrogenase (EC.1.1.1.49), Malatdehydrogenase (EC.1.1.1.37) und α-Glycerophosphatdehydrogenase (EC.1.1.1.8) im Fettgewebe wird mit einer herabgesetzten Triglyceridsynthese unter den Bedingungen der akuten Lipolyse in vivo erklärt. Hexokinase (EC.2.7.1.1), Phosphofructokinase (EC.2.7.1.11) und Pyruvatkinase (EC.2.7.1.40) als Schlüsselenzyme der Glycolyse waren im Fettgewebe nicht signifikant verändert. Neben den genannten Enzymen wurden in der Leber zum gleichen Zeitpunkt außerdem die Glycerokinase (EC.2.7.1.30), die Fructose-1,6-Diphosphatase (EC.3.1.3.11) und die Glucose-6-Phosphatase (EC.3.1.3.9) untersucht; keines der in der Leber bestimmten Enzyme zeigte eine signifikante Aktivitätsänderung.
    Notes: Summary Nine key enzymes in adipose tissue and liver of rabbits are investigated 2 hours after subcutanous injection of 500 μg Fraction H; the results are compared to those from normal animals. The activities of glucose-6-phosphate-dehydrogenase (EC.1.1.1.49), malatdehydrogenase (EC.1.1.1.37) and α-glycero-phosphate-dehydrogenase (EC.1.1.1.8) are diminished in adipose tissue suggesting a lowered glycerid-glycerolsynthesis under the conditions of acute lipolysis in vivo. Hexokinase (EC.2.71.1) phosphofructokinase (EC.2.7.1.11) and pyruvatkinase (EC.2.7.1.40) were not affected significantly in adipose tissue. Besides these enzymes glycerokinase (EC.2.7.1.30), fructose-1,6-diphosphatase (EC.3.1.3.11) and glucose-6-phosphatase (EC.3.1.3.9) were investigated in liver; no significant changes could be demonstrated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02044805
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Therapy of severe familial heterozygous hypercholesterolemia by low-density lipoprotein apheresis with immunoadsorption: effects of the addition of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors to therapy (1993)
    Springer
    Journal of molecular medicine 71 (1993), S. 908-912 
    Details
    ISSN: 1432-1440
    Keywords: Low-density lipoprotein apheresis ; Immunoadsorption ; 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors ; Combined therapy ; Familial hypercholesterolemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To establish whether additional therapy with 3-hydroxy-3-methylglutaryl (HMG) coenzyme A (CoA) reductase inhibitors enhances the low-density lipoprotein (LDL) cholesterol lowering effect of LDL apheresis with immunoadsorption in the treatment of patients with familial heterozygous hypercholesterolemia and coronary artery disease we studied eight patients initially on immunoadsorption therapy alone for 3 years. The adding of HMG CoA reductase inhibitors decreased pretreatment LDL cholesterol from 6.76±0.98 to 4.97±0.98 mmol/l and posttreatment LDL cholesterol from 2.33±0.80 to 1.94±0.67 mmol/l and increased pre- and posttreatment high-density lipoprotein (HDL) cholesterol by 0.08 and 0.13 mmol/l respectively. The LDL/HDL ratio was reduced from 4.0 to 2.8 (prior to any therapy the ratio was 13.4). The increase in LDL cholesterol between weekly treatments was less steep under the combined therapy. At the same time the treated plasma volume during LDL apheresis could be decreased from 5070±960 to 4370±1200 1200 ml. We conclude that in patients with severe familial heterozygous hypercholesterolemia LDL apheresis should be combined with HMG CoA reductase inhibitors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00185602
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    Paper (German National Licenses)
    Fulltext
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