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  • 1
    Electronic Resource
    Electronic Resource
    Effects of 6-hydroxydopamine on noradrenaline metabolism linked to neuronal uptake1 and extraneuronal uptake1 in dental pulp in vitro (1994)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 350 (1994), S. 352-355 
    Details
    ISSN: 1432-1912
    Keywords: Human dental pulp ; Rabbit dental pulp ; Noradrenaline metabolism ; 6-Hydroxydopamine ; Uptake
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The study was undertaken to determine the relative roles of neuronal and extraneuronal uptake1 in the metabolism of 3H-noradrenaline in human dental pulp. Rabbit dental pulp was used as a reference since it was already known that normetanephrine (NMN) formation in this tissue utilised extraneuronal uptake,. Slices of pulp were preincubated in the absence and presence of 6-hydroxydopamine (1.6 mmol/l, for 10 or 20 min at pH 4.5) and subsequently incubated with 3H-noradrenaline (0.18 μmol/l for 30 min at pH 7.4). The principal metabolites formed were normetanephrine in rabbit pulp and deaminated catechols (dihydroxymandelic acid and dihydroxyphenylglycol) in human pulp. In both tissues 6-hydroxydopamine strongly inhibited formation of the deaminated catechols, but was without effect on normetanephrine formation. It is concluded that: i) in vitro 6-hydroxydopamine does not influence the metabolic process which is dependent on extraneuronal uptake1, namely normetanephrine formation in rabbit dental pulp, and in human pulp. Attention is drawn to an unusual feature of the neuronal metabolism in human pulp, namely the appearance of dihydroxymandelic acid as the principal metabolite.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00178950
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  • 2
    Electronic Resource
    Electronic Resource
    Cocaine-sensitive O-methylation of noradrenaline in dental pulp of the rabbit: Comparison with the rabbit ear artery (1987)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 335 (1987), S. 32-39 
    Details
    ISSN: 1432-1912
    Keywords: Rabbit dental pulp ; Ear artery ; Noradrenaline uptake ; Metabolism ; Cocaine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Incisor pulp from the rabbit metabolises exogenous noradrenaline in concentrations between 0.12 and 1.2 μmol/l mainly to NMN. Effects of chronic sympathetic denervation indicated that in incisor pulp the NMN is extraneuronal in origin, and that DOPEG and DOMA formation, as well as a major part of the noradrenaline which accumulates in the tissue, are associated with the sympathetic nerves. NMN formation was unaffected by hydrocortisone 210 μmol/l, but was strongly inhibited by cocaine 30 μmol/l. These effects contrasted with those in the rabbit ear artery, where NMN formation was increased by cocaine 30 μmol/l and decreased by hydrocortisone 210 μmol/l. In COMT-inhibited denervated pulp, cocaine inhibited the accumulation of noradrenaline. Monoamine fluorescence histochemistry of pulp exposed to noradrenaline 50 μmol/l indicated that cocaine-sensitive uptake occurred in fibroblasts. It is concluded that O-methylation of noradrenaline in dental pulp involves prior uptake of the amine by a process resembling uptake, but which is distinguished from uptake1 by its extraneuronal location.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00165032
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The spreading of nonlinear elastic surface waves (1990)
    Springer
    Journal of elasticity 24 (1990), S. 79-103 
    Details
    ISSN: 1573-2681
    Keywords: 73C50 ; 73D20
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract A theory for the lateral spreading of a beam of nonlinear surface acoustic waves across the surface of an arbitrary, homogeneous, elastic half-space is developed. The resulting evolution equation generalizes that obtained for uni-directional waves by replacing an ordinary derivative by a diffusion operator of Schrödinger type. The coefficients arising in the evolution equation are related to partial derivatives of the dispersion relation for linearized surface waves on the half space. Details are given for isotropic materials and for two special cases of beams travelling along axes of high elastic symmetry.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00115554
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    Paper (German National Licenses)
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