Electronic Resource
Springer
European journal of nuclear medicine
20 (1993), S. 1113-1127
ISSN:
1619-7089
Keywords:
Radiation synovectomy
;
Rheumatoid arthritiswRadiotherapy
;
Hydroxylapatite
;
Samarium-153
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Radiation synovectomy is a potential weapon in the therapeutic armamentarium of nuclear medicine. It is an attractive alternative to surgical or chemical synovectomy for the treatment of rheumatoid arthritis. In this article the clinical results obtained with radiation synovectomy from the 1950s through 1992 are summarized and reviewed. Even after taking into account the paucity of well-controlled trials and rigorous clinical follow-up, it is clear that radiation synovectomy is efficacious in controlling the symptoms of rheumatoid arthritis. However, the procedure is not widely used because of concerns about leakage of radioactivity from the treated joint, and the resulting high doses that can be delivered to nontarget organs. New approaches to the preparation of radiolabeled particles for use in radiation synovectomy promise to minimize this leakage and thus allow the full potential of this important radiotherapy to be realized.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00173494
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