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The effects of intrathecal administration of the dopamine agonist apomorphine on penile reflexes and copulation in the male rat (1989)

Pehek, Elizabeth A. ; Thompson, James T. ; Hull, Elaine M.

Springer

Psychopharmacology 99 (1989), S. 304-308

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Details

ISSN: 1432-2072

Schlagwort(e): Apomorphine ; Dopamine ; Penile reflex ; Sexual behavior ; Spinal cord ; Rat

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Relatively high doses of systemically administered apomorphine inhibit penile reflexes. It is possible that these inhibitory effects are due, at least in part, to actions of apomorphine on the lumbosacral spinal cord. The present experiments examined this possibility by injecting apomorphine (10 and 50 μg/5.0 μl vehicle) into the lumbosacral subarachnoid space through chronic, indwelling cannulae. Such injections impaired ex copula penile reflexes, slowed the rate of copulation, and decreased the number of intromissions preceding ejaculation. These results suggest that lumbosacral cord dopamine receptors may normally regulate male sexual performance.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00445548

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