Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Spontaneous epileptiform activity of ca1 hippocampal neurons in low extracellular calcium solutions (1983)
    Springer
    Experimental brain research 51 (1983), S. 153-156 
    Details
    ISSN: 1432-1106
    Keywords: Hippocampal slice ; Epileptiform activity ; CA1 pyramidal cells ; Low calcium ; EGTA ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Lowering extracellular [Ca2+] in rat hippocampal slices induces spontaneous epileptiform activity in area CA1, which is characterized by rhythmic burst firing of CA1 neurons and by prolonged negative potential shifts at the pyramidal cell body layer. This activity is accompanied by transient decreases of [Na+] and increases of [K+] in the extracellular space. In spite of the complete blockade of synaptic transmission, the wave of epileptiform activity propagates across area CA1. These findings suggest, that non-synaptic mechanisms may play a role in the generation and spread of epileptiform activity in the mammalian CNS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00236813
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Hippocampal slices of kindled rats reveal calcium involvement in epileptogenesis (1985)
    Springer
    Experimental brain research 57 (1985), S. 404-407 
    Details
    ISSN: 1432-1106
    Keywords: Epileptogenesis ; Kindling ; Hippocampal slice ; Extracellular calcium ; Extracellular potassium ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Daily repeated tetanic electrical stimulation (kindling) of the brain may cause a long term enhancement of synaptic transmission and epileptiform activity of progressive severity and generalisation, eventually leading to spontaneous seizures. Evidence for a cellular mechanism underlying kindling has been obtained in vitro in slices from the hippocampus of kindled rats. A marked enhancement in extracellular calcium changes, induced by electrical stimulation or by iontophoresis of excitatory aminoacids was found in kindled tissue. This implies that changes in dendritic calcium conductances are involved in kindling epileptogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00236547
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...