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  • 1
    Electronic Resource
    Electronic Resource
    Inhalation hazard test (1988)
    Springer
    Archives of toxicology 61 (1988), S. 318-320 
    Details
    ISSN: 1432-0738
    Keywords: Inhalation ; Hazard ; Method ; Reproducibility ; Vapors ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Six industrial laboratories validated the Inhalation Hazard Test (OECD Method 403) using eight volatile chemicals. The test gave similar results in all laboratories, despite variation in inhalation exposure systems and strain of rat used. Detailed atmosphere analyses are not necessary, since nominal atmosphere concentrations were close to the analysed values. The method gives reproducible results directly applicable to hazard evaluation, and is quicker and cheaper and uses fewer animals than the conventional LC50 test.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00364856
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The Inhalation Hazard Test; principle and method (1988)
    Springer
    Archives of toxicology 61 (1988), S. 411-416 
    Details
    ISSN: 1432-0738
    Keywords: Inhalation ; Hazard ; Method ; Generation ; Vapor ; Safety ; Classification ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The Inhalation Hazard Test (IHT) measures the hazard rather than the toxicity of volatile substances. Generation methods for saturated vapor atmospheres and exposure systems are described. The determination of the nominal concentration gives in most cases sufficient information on the concentration in the inhalation atmosphere. The temperature at which the saturation occurs and the exposure time are parameters which influence the test results. The determination of the LT0 (the exposure time at which no animals die) is used to compare substances with different inhalation hazards. A classification system is proposed to differentiate the toxic hazard of volatile substances. The IHT is an appropriate method to characterize the acute inhalation hazard of volatile substances. It requires fewer animals and is less elaborate than the LC50.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00334623
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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