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  • 1
    ISSN: 1435-2451
    Keywords: Cytoprotection ; Prostaglandin ; Mucosal blood flow ; Cytoprotektion ; Prostaglandin ; Magendurchblutung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der Mechanismus der Cytoprotektion von Prostaglandin (PG) auf die Magenmucosa ist unbekannt. Anaesthesierte Kaninchen erhielten in der Gruppe (GR) I (n=8) im. Aspirin (ASA) (100 mg/kg als Bolus, 66 mg/kg/h kontinuierlich) in der GR 11 (n=10) NaCI und in der GR III (n=7) zusätzlich zum ASA, PGE I (0,1 μg/kg/min) als Infusion über 120 min. Der Mucosa-Blutfluß (MBF) wurde mit radioaktiven Mikrosphären gemessen. In der GR I fiel der MBF nach 15 min um 72,3+3,8% (+ SEM) und nach 120 min um 73,1+3,8% (p 0,05 gegen % Änderung in GR II und III). Nach 120 min zeigte sich in der GR I 19,8 + 7,6% der Fundusmucosa hämorrhagisch, in der GR 11 6,1 +5,2% und in der GR 1112,0+ 1,4% (p 0,05 gegen GR II und III). Wir schließen, daß der cytoprotektive Effekt des PGE I auf einer Aufhebung der ASA bedingten Mucosaischämie beruht.
    Notes: Summary The mechanism by which prostaglandins (PG) exert their cytoprotective effect on the gastric mucosa is not known. Anesthetized rabbits received in Group (GR) I (n = 8) i.v. aspirin (ASA) (100 mg/kg as bolus, 66 mg/kg/h continuously), in GR II (n=10) NaCl and in Gr III PGE I (0.1 μg/kg/min) as an infusion for 120 min. Mucosal blood flow (MBF) was measured with radioactive microspheres. After 15 min, fundus MBF had decreased in GR I by 72.3+3.8% (+SEM) and after 120 min by 73.1+3.8% (P 0.05 vs % change in GR II and III). After 120 min, 19.8+7.6% of the mucosa had become hemorrhagic in GR I, 6.1+5.2% in GR II and 2.0+1.4% in GR III (P 0.05 vs GR II and III). We conclude that the cytoprotective effect of PGE I may be mediated through prevention of ASA-induced mucosal ischemia.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Clinical rheumatology 3 (1984), S. 385-387 
    ISSN: 1434-9949
    Keywords: Reactive Arthritis ; Yersinia Enterocolitica
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two cases are reported of a reactive arthritis due to infection with Yersinia enterocolitica. These are the fifth and sixth cases reported in the United Kingdom. This interesting cause of arthritis may be more common than previously thought and should be considered even in the United Kingdom, although the practical implications are limited.
    Type of Medium: Electronic Resource
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