ISSN:
1573-9023
Keywords:
Structure-based
;
Design
;
Crystallography
;
Receptor
;
Binding
;
Inhibitor
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary In this article we report how protein-ligand X-ray structures can be used to identify and develop new drug candidates. The structure-based drug design approach (SBDD) is described, illustrating the way crystallographic information is utilized in an iterative manner to identify and optimize novel lead compounds, thereby accelerating the overall drug discovery process. The requirements for the effective use of SBDD and its implementation, drawing upon case histories from our Thymidylate Synthase (TS) research program, are described.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02174536
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