ISSN:
1573-4919
Keywords:
cholesterol
;
Receptor-‘C’k
;
thiol-oxidase
;
platelets
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract The study, addressed to understand whether or not human platelets possess a unique thiol-oxidase whose activity could be modulated by signalling pathway initiated upon the activation of Receptor-‘C’k revealed the existence of disulphide-dependent oxidation within these cells and this phenomenon was regulated by Receptor-‘C’k-dependent generation of second messengers especially phosphatidic acid (PA); cAMP and cGMP. Purification of this activity revealed the existence of 47 kDa protein having thiol-oxidase activity. Keeping in view these results we propose that the existence of this novel 47 kDa Thiol-oxidase within human platelets may provide a ‘crucial switch’ for the regulation of Receptor-‘C’k-dependent mevalonate pathway in human platelets.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00226066
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