ISSN:
1573-9023
Keywords:
Antithrombotic proteins
;
Protein C
;
Protein S
;
Thrombomodulin
;
Recombinant proteins
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary Over the last 10 years, much has been learned about the human protein C anticoagulation system, a key pathway in maintaining blood in a fluid state in vivo. Three major glycoproteins, namely protein C, protein S and thrombomodulin, are involved in this pathway. The aim of this article is to discuss therapeutic potentials and issues and challenges for developing recombinant protein C, protein S and soluble thrombomodulin as novel antithrombotics. We also briefly discuss other drug design strategies that may be employed in modulating the activity of the protein C anticoagulant pathway under pathological conditions.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02171862
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