ISSN:
1432-2072
Keywords:
Schizophrenia
;
Amphetamine
;
Neuroleptic discontinuation
;
Relapse prediction
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Twenty-five schizophrenic outpatient subjects in a depot neuroleptic discontinuation study received an amphetamine challenge approximately 6 weeks after their last dose. Only five of these showed greater than three-point increases in positive symptoms on the BPRS, and all five relapsed within 30 days of the challenge. The 20 with less than three-point increases in positive symptoms showed extremely variable stability, relapsing from 20–〉600 days after the challenge. Thus, increase in positive symptoms after amphetamine may identify a group at risk for rapid relapse after neuroleptic discontinuation, but lack of such a response gives little prognostic information.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00428187
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