ISSN:
1434-4726
Keywords:
Head and neck cancer
;
Chemotherapy
;
Individual dose intensity
;
Relatives performance
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Tegafur (Sunfural-S), as masked compound of a 5-fluorouracil derivative, was administered orally as a maintenance chemotherapeutic agent at a dose of 600 mg/day in 98 ases of head and neck epithelial cancer. The effectiveness of the drug was evaluated by a statistical method involving two formulae: individual dose intensity (IDI) and relative performance (RP). When comparing patients rated above a reference IDI value of 1.0 with those rated below 1.0, it was not possible to predict patient survival or tumor-free rates. In contrast, the value of the RP did show such a correlation. These findings support the effectiveness of Tegafur as a maintenance chemotherapeutic treatment for head and neck cancer patients.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00180387
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