ISSN:
1432-1440
Keywords:
Isosorbide dinitrate
;
Renal failure
;
Pharmacokinetics
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The pharmacokinetics of isosorbide dinitrate (ISDN) and its two active metabolites isosorbide-2-nitrate (IS-2-N) and isosorbide-5-nitrate (IS-5-N) were studied in 20 patients with normal and impaired renal function after repeated oral doses of standard 20 mg tablets ISDN t.i.d. Blood samples were taken in the steady-state on days 2 and 14, and the plasma concentrations were measured by electron capture capillary gas chromatography. We found a wide variation of pharmacokinetic parameters (AUC 0–8 ss andt 1/2) of ISDN, IS-2-N, and IS-5-N in our patients. No correlation was detected between AUC 0–8 ss ort 1/2 and the degree of renal insufficiency. No drug accumulation was observed after 14 days of administration.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01741389
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