ISSN:
1432-1238
Keywords:
Hemodynamics
;
Gas exchange
;
Mechanical ventilation
;
Oxygen
;
Perfluorocarbon
;
Respiratory distress syndrome
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Objective To assess the effect of partial liquid ventilation with perfluorocarbons on hemodynamics and gas exchange in large pigs with induced acute lung injury (ALI). Design Randomized, prospective, double-control, experimental study. Setting Experimental intensive care unit of a university. Materials Eighteen large pigs (50±5 kg body weight) with an average anterior posterior thoracic diameter of 24 cm and induced acute lung injury. Interventions All animals were surfactant depleted by lung lavage to aP aO2 below 100 mmHg and randomized to receive either perflubron (n=6) or saline (n=6) in five intratracheal doses of 5 ml/kg at 20-min intervals, or no instillation (n=6). Measurements and results In all animals heart rate, arterial pressures, pulmonary pressures, cardiac output and blood gases were recorded at 20-min intervals. There was no deleterious effect on any hemodynamic parameter in the perflubron group, whereas systolic and mean pulmonary arterial pressure values showed a persistent decrease after the first 5 ml/kg of perflubron, from 48.7±14.1 to 40.8±11.7 mmHg and from 39.7±13.2 to 35.2±12.0 mmHg, respectively. Perflubron resulted in a significant (ANOVAP〈0.01), dose-dependent increase inP aO2 values from 86.3±22.4 to a maximum of 342.4±59.4 mmHg at a dose of 25 ml/kg; the other groups showed no significant increase inP aO2. Conclusions Tracheal instillation of perflubron in induced ALI results in a dose-dependent increase inP aO2 and has no deleterious effect on hemodynamic parameters.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01700657
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