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  • Reversed-phase  (2)
  • Micro-columns  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Separation of D- and L-DOPA as their L-leucine derivatives by reversed-phase HPLC (1981)
    Springer
    Chromatographia 14 (1981), S. 529-534 
    Details
    ISSN: 1612-1112
    Schlagwort(e): HPLC ; Reversed-phase ; L-DOPA, purity of ; L-leucine derivatives
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary The separation and quantitation of D-DOPA as an impurity in L-DOPA is described. The method involves formation of the diastereomeric derivatives of DOPA with tert-butoxycarbonyl-L-leucine hydroxysuccinimide ester. Separation of the diastereomers was performed by reversed-phase liquid chromatography on LiChrosorb RP-18 and acetonitrile-phosphate buffer with addition of N,N-dimethyloctylamine as the mobile phase. The reproducibility of the method was 5.9% (relative standard deviation) at D-DOPA levels of 0.5% in L-DOPA drug substance.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02265633
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Miniaturization of a standard liquid chromatographic system (1980)
    Springer
    Chromatographia 13 (1980), S. 741-744 
    Details
    ISSN: 1612-1112
    Schlagwort(e): Miniaturization ; HPLC ; Micro-columns ; 0.67 mm3 micro flow-cell ; Sulphonamides
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary Methods for the construction of micro-columns equipped with low dead volume end fittings and an easy way to miniaturize a standard flow-cell to a volume of 0.67 mm3 are described. Operation characteristics of the microcolumns were evaluated by plate height versus linear velocity and plate height versus capacity factor plots. The influence of the volume of the flow-cell on the resolution is also demonstrated. An improvement of the resolution factor (RS) from 0.9 to 1.45 between sulphapyridine and sulphamerazine was obtained by using the 0.67 mm3 flow-cell instead of the 12.5 mm3 original flow-cell. The influence of the sample volume on the separation efficiency is also shown.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02265552
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Determination of chloramphenicol and its monosuccinate ester in piglet plasma using HPLC (1982)
    Springer
    Chromatographia 15 (1982), S. 737-742 
    Details
    ISSN: 1612-1112
    Schlagwort(e): LC ; Reversed-phase ; Chloramphenicol and monosuccinate ester ; Piglet plasma
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary A method for the determination of chloramphenicol and its monosuccinate ester in piglet plasma is described. It involves precipitation of plasma proteins by addition of methanol to the plasma sample, followed by injection of the supernate onto the column. Chloramphenicol and its ester are separated using a LiChrosorb RP-18 column and phosphate buffer pH 4.9 containing 30% methanol as eluent. Determination of chloramphenicol and its monosuccinate ester in pig plasma was made with a precision of 2.6% and 2.4% (relative standard deviation) at drug levels of 2 and 4 μg·cm−3, respectively. Stability data for the chloramphenicol monosuccinate ester are also presented.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02261367
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