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  • NMDA receptors  (1)
  • SCH 23390  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Effects of extinction, pimozide, SCH 23390, and metoclopramide on food-rewarded operant responding of rats (1987)
    Springer
    Psychopharmacology 92 (1987), S. 343-349 
    Details
    ISSN: 1432-2072
    Keywords: Extinction ; Pimozide ; SCH 23390 ; Metoclopramide ; Reward ; Dopamine ; D1 receptors ; D2 receptors ; Variable interval schedule ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The similarity in the pattern of responding produced by extinction and dopamine (DA) receptor blockers has led to the suggestion that DA neurons may participate in the usual effects of reward on behaviour. The purpose of the present study was to evaluate the effect of receptor-subtype specific DA antagonists on food-rewarded operant responding. Rats were trained to lever press for food on a variable interval 30-s schedule. They then received one of the following treatments prior to testing on the next 5 days: saline, nonreinforcement, the DA receptor blocker pimozide (0.5 or 1.0 mg/kg), the D1 receptor blocker SCH 23390 (0.01, 0.05, 0.1 mg/kg), and the D2 receptor blocker metoclopramide (1.0, 5.0, 10.0 mg/kg). Nonreinforcement resulted in both intra- and intersession declines in responding. The drugs produced dose-dependent decreases in overall responding. Additionally, both doses of pimozide and the higher doses of SCH 23390 and metoclopramide altered intrasession patterns of responding when compared to saline, with their greatest effect being in the latter portion of the session. Intersession declines were seen with the highest doses of SCH 23390 and metoclopramide and control studies showed that these declines could not be attributed to a buildup of the drug with repeated dosing. It was concluded that both D1 and D2 receptors participate in the control of behaviour by reward.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00210842
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Typical and atypical neuroleptics antagonize MK-801-induced locomotion and stereotypy in rats (1992)
    Springer
    Journal of neural transmission 89 (1992), S. 1-10 
    Details
    ISSN: 1435-1463
    Keywords: Clozapine ; MK-801 ; eticlopride ; haloperidol ; NMDA receptors ; stereotypy ; locomotion ; dopamine ; glutamate ; D 2 receptors ; schizophrenia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of typical and atypical neuroleptics on MK-801-induced locomotor activity and stereotyped sniffing were tested. Pretreatment with the typical neuroleptic haloperidol (0.01,0.05, 0.1,0.5 mg/kg SC) and the dopamine D 2 receptor selective antagonist eticlopride (0.005, 0.01, 0.05 mg/kg SC) each resulted in significant and dose-dependent reductions of locomotor activity and sniffing. The atypical neuroleptic clozapine (1.0, 5.0, 10.0 mg/kg SC) was some-what unique in that all doses reduced locomotor activity, but only the highest dose (10.0 mg/kg) significantly reduced sniffing. The data support a functional interaction between glutamate and dopamine systems, and suggest that the behavioral activation associated with MK-801 may represent a valid model for detecting potential therapeutic agents in the treatment of schizophrenia. The data should be viewed as preliminary, however, until neuroleptics are characterized in other glutamate-based models that minimize or exclude the possible influence of nonspecific motor effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01245347
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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