ISSN:
1573-4919
Keywords:
SRE sequence affinity
;
47 kDa factor
;
thiol-oxidase activity
;
platelets
;
lymphocytes
;
CML patients
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract The present study provides evidence to support that human platelets possess a 47 kDa dual functional molecule having thiol-oxidase activity as well as high affinity for the SRE sequence in the human genome. On the basis of these as well as earlier results, we propose that Receptor 'Ck' dependent regulation of this dual functional 47 kDa molecule may provide a mechanism for the maintenance of cellular cholesterol homeostasis. Further, this mechanism nay also explain the molecular basis of cholesterol-feedback lesion observed under premalignant conditions.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1006853001631
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