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  • 1
    Digitale Medien
    Digitale Medien
    Different effects of early endotoxaemia on hepatic and small intestinal oxygenation in pigs (1996)
    Springer
    Intensive care medicine 22 (1996), S. 795-804 
    Details
    ISSN: 1432-1238
    Schlagwort(e): Key words Lipopolysaccharide ; Liver ; Small intestinal serosa and mucosa ; Tissue oxygen tension ; Acid ; base balance
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract   Objective:  Study on simultaneous O2 supply/uptake relationships in liver and gut during endotoxaemia, to determine whether signs of dysoxia develop uniformly in the splanchnic region. Design: Animal study to assess the early effects of endotoxaemia on oxygenation of both liver and small intestine. Interventions: Eight anaesthetized pigs received a continuous portal venous infusion of lipopolysaccharide (0.5 μg⋅kg-1⋅h-1) for 6 h. Systemic, pulmonary and splanchnic haemodynamics as well as systemic and splanchnic O2 supply/uptake relationships were determined. Results: There was a multiphasic haemodynamic response pattern characterized by an early (within the 1st h) and a subsequent more prolonged phase (between the 2nd and 6th h) of decreases and recovery of hepatic arterial, portal venous and superior mesenteric arterial blood flows (electromagnetic flow probes) and splanchnic O2 deliveries. Unrelated to perfusion pressure and O2 delivery, there were early and sustained decreases in ileal mucosal surface partial pressure of oxygen (PO2) (multiwire PO2 electrode) and pH (tonometry). This was not reflected by ileal serosal surface PO2, O2 uptake and arteriomesenteric venous pH and partial pressure of carbon dioxide (PCO2) gradients. There was little evidence of concomitant hepatic dysoxia as evaluated by surface PO2. Conclusions: The study demonstrates early and sustained regional (mucosa) intestinal hypoxia with little evidence of simultaneous hepatic dysoxia during initial endotoxaemia.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01709523
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  • 2
    Digitale Medien
    Digitale Medien
    Different effects of early endotoxaemia on hepatic and small intestinal oxygenation in pigs (1996)
    Springer
    Intensive care medicine 22 (1996), S. 795-804 
    Details
    ISSN: 1432-1238
    Schlagwort(e): Lipopolysaccharide ; Liver ; Small intestinal serosa and mucosa ; Tissue oxygen tension ; Acid-base balance
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Objective Study on simultaneous O2 supply/uptake relationships in liver and gut during endotoxaemia, to determine whether signs of dysoxia develop uniformly in the splanchnic region. Design Animal study to assess the early effects of endotoxaemia on oxygenation of both liver and small intestine. Interventions Eight anaesthetized pigs received a continuous portal venous infusion of lipopolysaccharide (0.5 μg·kg−1·h−1) for 6 h. Systemic, pulmonary and splanchnic haemodynamics as well as systemic and splanchnic O2 supply/uptake relationships were determined. Results There was a multiphasic haemodynamic response pattern characterized by an early (within the 1st h) and a subsequent more prolonged phase (between the 2nd and 6th h) of decreases and recovery of hepatic arterial, portal venous and superior mesenteric arterial blood flows (electromagnetic flow probes) and splanchnic O2 deliveries. Unrelated to perfusion pressure and O2 delivery, there were early and sustained decreases in ileal mucosal surface partial pressure of oxygen (PO2) (multiwire PO2 electrode) and pH (tonometry). This was not reflected by ileal serosal surface PO2, O2 uptake and arteriomesenteric venous pH and partial pressure of carbon dioxide (PCO2) gradients. There was little evidence of concomitant hepatic dysoxia as evaluated by surface PO2. Conclusions The study demonstrates early and sustained regional (mucosa) intestinal hypoxia with little evidence of simultaneous hepatic dysoxia during initial endotoxaemia.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01709523
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  • 3
    Digitale Medien
    Digitale Medien
    Sampling techniques for SFC using peak focusing by pressure and/or temperature programming (1989)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 12 (1989), S. 218-225 
    Details
    ISSN: 0935-6304
    Schlagwort(e): Supercritical fluid chromatography, SFC ; Sampling techniques ; Peak focusing ; Pressure programming ; Temperature optimization ; Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: In analogy to the focusing effective in capillary GC, performed with temperature programming but also with sectional cooling of the column inlet as in multidimensional capillary GC, peak focusing can easily be attained in SFC by adjustment of the mobile phase pressure as well as the column temperature. This may be of practical use in connection with sampling techniques giving poor, i.e. broad and unsymmetrical, peak shapes. Such disturbances may occur, for example, in time controlled valve sampling over longer switching times. Generally, all other negative influences on peak shape can be suppressed or compensated by trapping within the column inlet. Special trapping devices and “retention gaps” may also be coupled to the column inlet in order to create narrow starting plug widths. Positive pressure (density) and negative temperature programs give rise to peak compression besides the increase of peak capacity of the separation.
    Zusätzliches Material: 8 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jhrc.1240120406
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Instrumentation for SFC systems: Different sampling and restriction designs (1988)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 11 (1988), S. 191-197 
    Details
    ISSN: 0935-6304
    Schlagwort(e): Capillary SFC ; Instrumentation ; Sampling techniques ; Restrictors ; Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: Different designs of injection and restriction devices for capillary supercritical fluid chromatography (SFC) have been investigated with respect to their practical applicability and usefulness for reproducible and accurate qualitative and quantitative analyses. In combination with a self-made instrument a fast switching valve is preferable as an injection device compared to a split-injector, and an integral restrictor made from the end of the fused silica (FS) separation column was superior to a linear restrictor made by coupling a small diameter FS-column to the separation column.
    Zusätzliches Material: 11 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jhrc.1240110210
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  • 5
    Digitale Medien
    Digitale Medien
    Quantitation in miniaturized GC and SFC systems (1989)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 12 (1989), S. 142-148 
    Details
    ISSN: 0935-6304
    Schlagwort(e): Capillary GC ; Capillary SFC ; Narrow bore capillary columns ; Sampling techniques ; Quantitation ; Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: Separations of high efficiency and/or speed can be achieved in capillary GC by capillary columns of lower internal diameter (〈 50 μm). Sampling techniques for the analytical application of narrow bore fused silica columns have been evaluated with regard to quantitation. On-column injection cannot be applied. Therefore liquid samples have to be vaporized in external devices before they enter the chromatographic system. Sample introduction by syringe with subsequent splitting must and can be applied but requires special syringes with perfect piston sealing because of the high inlet pressures needed even with hydrogen as carrier gas. For general analytical applications, valve systems should be developed to eliminate both the syringe and the septum from instrumental GC set-up's.In SFC using either narrow bore capillary or packed microbore columns, time-controlled valve sampling with partial displacement of the sample from the loop seems to be an adequate technique because of the very high inlet pressures involved. Splitting in combination with valve operation can also be applied in capillary SFC at least to samples of good solubility in the mobile phase. A disadvantage of splitting in SFC is that another restriction for the adjustment of the split flow is necessary.
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jhrc.1240120306
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