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Digitale Medien

Inhibiteurs β-adrénergiques et stéréotypies provoquées par l'amphétamine ou l'apomorphine chez le rat (1972)

Simon, P. ; Chermat, R. ; Fosset, M. Th. ; [weitere]

Springer

Psychopharmacology 23 (1972), S. 357-364

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Details

ISSN: 1432-2072

Schlagwort(e): Propranolol ; Prinodolol ; Practolol ; Beta-Adrenergic Blocking Agents ; Amphetamine ; Apomorphine ; Stereotyped Behavior ; Rats

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract The influence of three beta-adrenergic blocking agents was studied on the stereotyped behavior induced in rats by a range of doses of d-amphetamine or apomorphine. The stereotyped behavior was assessed either clinically (quotation from 0 to 3 at various times for each rat) or using the confinement motor activity test. From 8 mg/kg (i.p.) onwards, propranolol and prinodolol clearly potentiated the amphetamine-induced stereotyped behavior without any modification of the apomorphine-induced stereotyped behavior. Practolol, known for its poor passage through the blood-brain barrier had only a slight effect.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00406738

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