ISSN:
1432-0428
Keywords:
Copper
;
superoxide dismutase
;
rats
;
Streptozotocin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Experimental diabetes can be produced by agents with specific toxicity for pancreatic islet B cells. This effect has been reported to be modified both in vitro and in vivo by various radical scavengers including the enzyme Superoxide dismutase. Copper(II)(3,5-diisopropylsalicylate)2 is lipophilic and possesses Superoxide dismutase bioactivity. Prior administration of this compound to male rats appeared to attenuate the severity of streptozotocin-induced diabetes as assessed by glycosuria and glucose tolerance. Diisopropylsalicylate, which has no Superoxide dismutase activity, did not alter the severity of streptozotocin-induced diabetes. Rats treated with the copper complex, with Streptozotocin or with a combination of the two agents gained 50% less weight than untreated controls, or rats treated with diisopropylsalicylate. The attenuation of diabetes by the copper-complex may represent partial protection of the B cells against Streptozotocin damage, although an extrapancreatic, toxic effect cannot be ruled out.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00257343
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