ISSN:
1432-2072
Keywords:
Dopamine receptors
;
Striatum
;
Denervation
;
Supersensitivity
;
Subsensitivity
;
L-Dopa
;
Rat
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Denervation-induced supersensitivity of the striatal dopamine receptors can be quantified by the turning behaviour induced by apomorphine. With this experimental model we found that high-dose L-dopa/carbidopa administration reduced this supersensitivity. This effect was seen on the 1st day and did not alter over 5 or 10 days of treatment, but dissappeared when medication was discontinued. The degree of reduction was the same, independent of the dose and period of administration. This effect could provide a useful model for studying the phenomenon of the irreversibility of the supersensitivity of the striatal dopamine receptors.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00217074
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