ISSN:
1435-1463
Keywords:
Suprachiasmatic nucleus
;
microdialysis
;
methamphetamine
;
serotonin
;
5-hydroxyindoleacetic acid
;
circadian pacemaker
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The suprachiasmatic nucleus (SCN) has been identified as a major circadian pacemaker. Methamphetamine has been shown to modify the behavior of circadian rhythms. We detected extracellular serotonin (5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) in the SCN in freely moving rats, using a microdialysis method, to investigate biochemical effects of methamphetamine in the SCN. Methamphetamine infusion into the SCN dose-dependently increased extracellular 5-HT and decreased extracellular 5-HIAA.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01250703
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