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  • Prosthesis  (1)
  • T-tube patients  (1)
  • 1
    ISSN: 1248-9204
    Keywords: Inguinal hernia ; Mesh ; Prosthesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Aims Tension-free mesh reinforcement is the mainstay of laparoscopic hernia repair. Problems with current prostheses include shrinkage, migration, patient discomfort and neuralgias. We prospectively analyzed the short-term utility of a soft, non-woven mesh (Biomesh W/NK®, Cousin Biotech) in the TAPP repair. Methods During surgery, ease of insertion, unrolling, positioning and fixation of the mesh were evaluated. Postoperatively, all patients were followed up at 8 and 30 days. Results Forty-five hernias were repaired in 32 patients. Hernias were classified as Nyhus I-2; II-5; Nyhus III-33; Nyhus IV-5. Mean mesh size for unilateral hernias was 14,4 × 12.8 × 9 cm. All meshes were inserted without difficulty, and unrolled into the correct space with minimal trouble. Once in position, moving the mesh was more difficult than with a conventional woven mesh. Fixing was relatively straightforward. The mesh was noted to mould to tissues, assisting with hemostasis. At follow-up, there were no complications noted, specifically no neuralgias or seromas. Discussion Woven or knitted polypropylene mesh is commonly used for laparoscopic hernia repair, due to its ease of manipulation. However, the stiffness of such mesh probably contributes to its well-recognized complications. The Biomesh is much softer, lighter and more pliable, and can potentially reduce complications related to mesh stiffness. We have demonstrated the ease of insertion and fixation of the mesh, and the absence of short-term complications related to its use. In light of our experience, we believe that, in selected cases, the Biomesh offers an attractive alternative to traditional mesh.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 37 (1989), S. 589-594 
    ISSN: 1432-1041
    Keywords: ketoprofen ; probenecid ; cholecystectomy ; enantiomers ; glucuroconjugates ; stereoselectivity ; T-tube patients ; biliary excretion ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Ketoprofen (KT), a 2-arylpropionic acid nonsteroidal antiinflammatory drug, is administered as a racemate. Previous reports suggest stereoselective biliary excretion of KT enantiomers. This hypothesis was tested by administering 50 mg racemic KT to five patients who required bile drainage following cholecystectomy surgery. Subsequently, to study the influence of probenecid (PB), an inhibitor of KT renal elimination, on the biliary excretion, 1000 mg PB was administered 1.5 h before KT to the same patients. The unchanged and conjugated (as glucuronides) KT enantiomers were measured in plasma, urine and bile. In general, KT enantiomers had different plasma concentration-time curves. As compared to normal subjects, these patients had comparable AUCs and shorter t1/2s. Biliary concentrations of conjugated S-KT were greater than R-KT. Nevertheless, the total cumulative biliary excretion of conjugated KT did not exceed 2% of the dose ruling out this pathway as a significant route of KT elimination. There was a positive and significant correlation between the cumulative urinary excretion of conjugated KT enantiomers and creatinine clearance. Although PB did not influence the pattern of stereoselectivity of KT, it increased AUC and prolonged t1/2 of the enantiomers. While reducing cumulative urinary excretion, PB increased total biliary elimination of conjugated KT enantiomers. This, however, did not totally compensate for the reduced urinary excretion. It is suggested that the impaired conjugation of KT caused by PB administration may result in the augmentation of other, otherwise minor, metabolic pathways.
    Type of Medium: Electronic Resource
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