ISSN:
1437-160X
Schlagwort(e):
CD5+ B-cells
;
TCR γδ + T-cells
;
Gold sodium thiomalate
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Summary Circulating CD5+ B-cell levels in 15 patients with rheumatoid arthritis (RA) not receiving remittive therapy was significantly increased when compared to 17 normal controls (mean±SE: RA, 19.7±2.85%; controls, 11.6±1.67%; P〈0.02). In contrast, 24 patients with RA receiving gold sodium thiomalate therapy (GST) had similar CD5+ B-cell levels (11.88±1.65) when compared to controls and significantly reduced levels when compared to the RA group not receiving remittive agents (P〈0.01). Furthermore, TCR γδ + T-cell levels were also assessed in these patients groups. These values were not significantly different between any of the groups (controls, 4.46±1.36%; GST, 6.88±1.73%; RA, 2.73±0.55%), although 42% of the GST treated group had γδ + T-cell levels higher than the entire untreated RA group. No correlation was observed between the levels of TCR γδ + T-cells and CD5+ B-cells in any of these groups. These results suggested that therapy does influence the level of CD5+ B-cells and γδ + T-cells in these patients.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00332557
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