ISSN:
1432-1432
Keywords:
3-Isoadenosine 5′-phosphate
;
Template-directed condensation
;
Poly(iA)
;
X-ray
;
Hoogsteen base pairing
;
Prebiotic
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary Template-directed oligomerization of an activated derivative of 3-isoadenosine 5′-phosphate (piA) on polyuridylic acid [poly(U)] was studied. The reaction of ImpiA is more efficient than the corresponding reaction of ImpA, and produces 3′–5′-linked oligomers while the reaction of ImpA gives only 2′–5′-linked oligomers. The base pairing between piA and poly(U) in this system is probably of the Hoogsteen type (involving the 6-amino group and N7 of 3-isoadenosine) rather than of the Watson-Crick type.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02138366
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