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  • 1990-1994
  • 1970-1974  (2)
  • Tetanus  (2)
  • 1
    Digitale Medien
    Digitale Medien
    125I-labeled neurotoxin from clostridium botulinum A: Preparation, binding to synaptosomes and ascent to the spinal cord (1974)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 281 (1974), S. 47-56 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Botulinum A ; Tetanus ; Neurotoxin ; Hemagglutinin ; Iodine Labeling
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary 1. Labeling of crystalline botulinum A toxin has been done with 125I by aid of the chloramine T method. The neurotoxic component is well preserved, whereas the hemagglutinin undergoes physicochemical alterations. Neither with labeled nor with unlabeled toxin, hemagglutinating power parallels the main protein peak. 2. Neurotoxin, homogeneous in gel filtration, is bound to synaptosomes from rat brain. Cold toxin competes with labeled toxin, and antitoxin or neuraminidase partially remove the bound neurotoxin. 3. Upon intramuscular injection, some radioactivity is recovered in the respective parts of the spinal cord. Antitoxin prevents the ascent. The similarities between tetanus and botulinum A neurotoxins are stressed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00500611
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    A rapid and simple radioimmunological procedure for measuring low concentrations of tetanus antibodies (1973)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 276 (1973), S. 321-326 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Tetanus ; Antibodies ; Radioimmunological Measurement
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A radioimmunological assay procedure allows the measurement of small amounts of tetanus antibodies; it should also be applicable to antibodies against other soluble antigens. It is based on the competition between dissolved and solid phase antibodies for labelled antigen. In the range of experimental error, the same antibody titers are found with the radioimmunological and with the mouse protection test. The detection limit is in the range of 0.001 IU/ml. The reaction conditions allow the determination of antibodies in multiple samples.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00499886
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
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