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  • Artikel: DFG Deutsche Nationallizenzen  (4)
  • Inner ear  (2)
  • Threshold shift  (2)
  • 1
    Digitale Medien
    Digitale Medien
    Springer
    International archives of occupational and environmental health 69 (1996), S. 45-52 
    ISSN: 1432-1246
    Schlagwort(e): Key words Vibratory sensation ; Vibration exposure ; Threshold shift ; Temporary threshold shift ; Gripping force
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract ⋅Objective This study examines the effect of the force with which a vibrating handle is gripped on the temporary threshold shift of vibratory sensation (TTSv) induced by hand-arm vibration. ⋅  Methods Six healthy subjects gripped a handle vibrating with a 1/3 octave-band vibration, with a central frequency of 200 Hz and an intensity of 39.2 m/s2. Exposure was for 1 min and 10 min, respectively. Gripping forces for the 1-min exposure were 5 N, 10 N, 40 N and 80 N, respectively, with 0 N push-pull force. Gripping forces for the 10-min exposure were the same as for the 1-min exposure, but omitting 80 N. The vibratory sensation threshold at 125 Hz was measured before and after exposure of an exposed fingertip to vibration. The differences measured determine TTS v,t at time t. TTS v,t determines TTSv,0, that is, the temporary threshold shift of vibratory sensation immediately after exposure to vibration according to the estimate made on the basis of the preceding study. The same experimental conditions were repeated 3 times on different days in a soundproof and thermoregulated room. ⋅  Results Our findings show that TTSv increases significantly with increasing gripping force. We also determined the quantitative relationships between TTSv,0 and gripping force as described by the equation where k f and c f are constants and F is gripping force. ⋅  Conclusion This study revealed the importance of ergonomic design in reducing the force with which a vibrating handle is gripped to prevent an adverse effect of local vibration. The equation devised may help in the quantitative assessment of the effect of reduced gripping force.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    International archives of occupational and environmental health 66 (1994), S. 97-102 
    ISSN: 1432-1246
    Schlagwort(e): Human skin ; Vibratory sensation Vibration exposure ; Threshold shift ; Acute effect
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract A new, self-recording, vibratory sensation meter measures temporary threshold shifts of vibratory sensation (TTSv) on a finger tip. After exposure to hand-transmitted vibration with exposure frequencies 63 Hz, 200 Hz and 500 Hz, and levels of acceleration 1 g, 2 g, 4 g and 8 g, fingertip measurements were obtained. Temporary threshold shift immediately after the vibratory exposure (TTSVv,0) was estimated for each exposure from the regression analysis by approximation of an exponential function. Time constant (tc) was also estimated at the same time by the analysis. The coefficients of determination were large. Thus, the fit of the exponential function is very good for each exposure. The tc corresponds to the recovering velocity of the temporary shift and implies the half-life period of TTSv. These parameters enable us to examine more generally the relationships of TTSv to the characteristics of exposure vibration, subject and other conditions. On this basis, the estimated TTSv,0 and tc were used to examine the dependency of TTSv on the characteristics of the exposure vibration and the subject. The most effective frequency under the level of 4 g is thought to be between 200 Hz and 500 Hz. TTSv,0 of each subject proportionally increased with power of acceleration. The coefficient of determination on regression analysis was large. This result enables us to estimate TTSv,0 at an arbitrary level of acceleration by use of a regression equation derived from experimental data.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Springer
    European archives of oto-rhino-laryngology and head & neck 248 (1991), S. 479-482 
    ISSN: 1434-4726
    Schlagwort(e): Inner ear ; Human fetus ; Laminin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The expression of laminin was analyzed in the human fetal inner ear using immunohistochemical methods. In the 11-week-old human fetus, the presence of laminin was found in the basement membrane of the immature cochlea, endolymphatic sac and vestibular end organs. The reaction of the basement membrane of the endolymphatic sac was strong in the 15-week-old human fetus. A laminin reaction was seen in the cochlea, Reissner's membrane, epithelial cells of the limbus spiralis, the basilar membrane and the stria vascularis. In particular, the capillaries and basement membrane of the stria vascularis were strongly positive. These results suggest that laminin may be an essential component in the development of the inner ear and may possibly be related to filtration of the endolymph.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Springer
    European archives of oto-rhino-laryngology and head & neck 252 (1995), S. 312-315 
    ISSN: 1434-4726
    Schlagwort(e): S-100 protein ; Inner ear ; Human fetus Development
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The expression of S-100 protein was analyzed in the human fetal inner ear using immunohistochemical methods. In the 11-week-old human fetus, the cochlea was almost negative for S-100 protein, whereas in the 14- and 15-week-old fetuses, the spiral ligament, Reissner's membrane and spiral limbus were positive for the protein. These results suggest that S-100 protein may be a reliable marker for determining functional maturation of the fetal cochlea and the inner ear. In the l l-, 14- and 15-week fetuses, the epithelial cells of the endolymphatic sac were labelled with S-100 protein. These findings demonstrate that the endolymphatic sac, spiral limbus and spiral ligament in the fetal inner ear have a high activity of S-100 protein, with this presence possibly related to fluid and ion transport of endolymph.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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