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  • 1
    ISSN: 1437-160X
    Keywords: Osteoarthritis ; Femoral neck fractures ; Osteoporosis ; Glycosaminoglycan composition ; Articular cartilage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The glycosaminoglycan (GAG) and uronic acid (UA) composition of human hip articular cartilage from patients with femoral neck fractures [assumed osteoporosis (OP); n=12], from patients with osteoarthritis (OA; n=12) and from normal controls (n=9) was determined. Full depth tissue samples from the control and OP groups were analysed from the superior, inferior, anterior and posterior regions, while the OA tissue was from cystic (tissue growing on top of cystic bone lesions) and osteophytic regions, from normal and fibrillated resident cartilage and from regions immediately adjacent to eburnated bone. The total sulphated GAG and UA content was reduced in the inferior region of control cartilage compared to the other regions and the values of all regions of the assumed OP group. Cystic regions and OA cartilage adjacent to the bone also showed lower GAG and UA levels than the other regions. The ratios of chondroitin 6-sulphate (C6S) to chondroitin 4-sulphate (C4S) indicated a similar pattern in the different regions of controls and the patient group with femoral neck fractures (OP group). The cystic and osteophytic cartilage of the OA group exhibited lower C6S/C4S ratios than any other region. The levels of dermatan sulphate (DS) in the cartilage of all regions of the OP and control groups were very similar and low, while the tissues of the OA group contained significantly higher amounts, particularly the cartilage from osteophytes. The previously presumed compositional similarity between normal aged and osteoporotic articular hip cartilage was essentially confirmed in a comparative analysis. Significant changes in GAG and UA composition of OA cartilage from distinct regions was also recorded.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of applied physiology 64 (1992), S. 395-401 
    ISSN: 1439-6327
    Keywords: Cold stress ; Cooling rate ; Intramuscular temperature ; Tissue temperature ; Transient response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The transient temperature response of the resting human forearm immersed in water at temperatures (T w) ranging from 15 to 36°C was investigated. Tissue temperature (T t) was continuously monitored by a calibrated multicouple probe during the 3-h immersions.T t was measured every 5 mm, from the longitudinal axis of the forearm to the skin surface. Skin temperature, rectal temperature, and blood flow ( $$\dot Q$$ ) were also measured during the immersions. The maximum rate of change of the forearm mean tissue temperature ( $$\dot T_{{\text{t, max}}}$$ ) occurred during the first 5 min of the immersion. $$\dot T_{{\text{t, max}}}$$ was linearly dependent onT w (P〈0.001), with mean values (SEM) ranging from −0.8 (0.1) °C · min−1 at 15°C to 0.2 (0.1) °C · min−1 at 36°C. The maximum rate of change of compartment mean temperature was dependent (P〈0.001) on the radial distance from the longitudinal axis of the forearm. The half-time for thermal steady state of the forearm mean tissue temperature was linearly dependent onT w between 30 and 36°C (P〈0.01), with mean values (SEM) ranging from 15.6 (0.6) min at 30°C to 9.7 (1.2) min at 36°C and not different between 15 and 30°C, averaging 16.2 (0.6) min. There was a significant linear relationship between the half-time for thermal steady-state of the compartment mean temperature and the radial distance from the longitudinal axis of the forearm for each value ofT w tested (P〈0.001). The data of the present study suggest that the forearm $$\dot Q$$ is an important determinant of the transient thermal response of the forearm tissue during thermal stress.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of applied physiology 63 (1991), S. 188-193 
    ISSN: 1439-6327
    Keywords: Cold-induced vasodilatation ; Cold stress ; Tissue heat loss ; Tissue temperature
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The purpose of the present study was to investigate the intramuscular temperature fluctuations in the human forearm immersed in water at 15°C. Tissue temperature (T t) was continuously monitored by a calibrated multi-couple probe during 3 h immersion of the forearm. The probe was implanted approximately 90 mm distal from the olecranon process along the ulnar ridge. T t was measured every 5 mm, from the longitudinal axis of the forearm (determined from computed tomography scanning) to the skin surface. Along with T t, rectal temperature, skin temperature and heat loss of the forearm were measured during the immersions. Five of the six subjects tested showed evidence of cyclic temperature fluctuations in the forearm limited to the muscle tissue. The first increase of the muscle temperature was observed 75 (SE 6) min after the onset of the immersion, and the duration of the cycle averaged 36 (SE 3) min. The maximum increase of the muscle temperature, which ranged between 0.4°C and 1.0°C, was measured at the axis of the forearm, and was inversely correlated to the circumference of the subject's forearm (P〈 0.05). No corresponding increases of the skin temperature and heat loss of the forearm were observed for the complete duration of the immersion. These data support the hypothesis of a significant contribution of the muscle vessels during cold-induced vasodilatation in the forearm.
    Type of Medium: Electronic Resource
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