ISSN:
1432-0584
Keywords:
Key words Acute lymphoblastic leukemia
;
Cytogenetics
;
Translocation t(4;11)
;
Secondary chromosome aberrations
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The translocation t(4;11)(q21;q23) is one of the most common specific chromosomal aberrations in acute lymphoblastic leukemia (ALL), occurring in 2% of childhood and in 5–6% of adult cases. Especially in adults, the t(4;11) is associated with a poor prognosis. In order to determine the significance of clonal chromosome aberrations that occur in addition to t(4;11), we studied the karyotypes and clinical courses of 23 patients with acute lymphoblastic leukemia and a translocation t(4;11)(q21;q23). Additional clonal chromosome aberrations were found in ten patients. An isochromosome i(7)(q10) and a trisomy 6 were observed most frequently as secondary anomalies. Clonal evolution was detected in four of six patients analyzed at diagnosis as well as at relapse. With treatment carried out according to modern risk-adapted therapy protocols, no difference in outcome was observed between patients with clonal chromosome aberrations in addition to t(4;11) at diagnosis and those without.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01700375
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