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  • 1
    Digitale Medien
    Digitale Medien
    Ultrastructural changes of bone marrow in canine cyclic hematopoiesis (CH dog) (1981)
    Springer
    Virchows Archiv 390 (1981), S. 93-108 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Cyclic hematopoiesis ; Bone marrow ; Ultrastructure ; Nuclearcytoplasmic asynchrony ; Döhle-like bodies
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The pathogenesis of cyclic hematopoiesis (CH) in the grey collie dog is still unknown. It has been proposed that periodic bursts of necrosis of the bone marrow neutrophils would induce cyclic arrests of the stem cell differentiation. In the present study, the sequential changes undergone by the erythroid and neutrophil series of the bone marrow of CH dogs were evaluated by electron microscopy. Erythroid cells presented quantitative periodic oscillations but the morphologic features of both immature and mature cells were normal. On the contrary, nonspecific necrotic changes were observed to occur in the myeloid series. Those abnormalities, which were more marked between days 9 and 11 of the cycle, mainly involved the immature cells and, to a lesser extent, the mature neutrophils. The number of necrotic cells was variable in different cycles, but always represented a small portion of the myeloid cells. In addition, few bone marrow macrophages displayed signs of phagocytic activity containing cell debris. The ultrastructural changes of the myeloid series were accompanied by an abnormal decrease of peroxidase activity and the permanence of large acid phosphatase-positive Golgi complexes in mature neutrophils, as defined by morphologic criteria. Döhle-like arrays of rough endoplasmic reticulum were present in many cells. Our findings suggest that an asynchronic development of myelocytes occurs as a result of regulatory abnormalities related to the congenital defect of the bone marrow which interferes with the differentiation and maturation of the stem cells. Necrosis in some myeloid cells would be a secondary phenomenon rather than a causal factor for the cyclic arrest of cell maturation as has been previously submitted. Furthermore, the small size of the necrotic cell population could not justify the production of “inhibitors” in sufficient amounts as to block the normal evolution of the bone marrow stem cell pool.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00443900
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  • 2
    Digitale Medien
    Digitale Medien
    Kristallographische Interpretation der Feinstruktur der B-Granula in den Langerhansschen Inseln der Ringelnatter, Natrix n. natrix (L.) (1972)
    Springer
    Cell & tissue research 131 (1972), S. 559-570 
    Details
    ISSN: 1432-0878
    Schlagwort(e): Islets of Langerhans ; Grass-snake ; Crystalline B-granules ; Ultrastructure ; Crystallography
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Kristalline B-Granula im Pankreas der Ringelnatter besitzen die Form von Rhombendodekaedern (a ≈ 11 nm, kubisch-raumzentriertes Gitter). Diese Diagnose wird abgeleitet von den Ergebnissen der dreidimensionalen Rekonstruktion von Serienschnitten, der optischen Diffraktometrie und aus dem Vergleich mit Kristallmodellen. Die Bedeutung kristalliner B-Granula wird erörtert.
    Notizen: Summary Crystalline B-granules of grass-snake islets of Langerhans have been shown to possess the shape of rhombic dodecahedra (a ≈ 11 nm, cubic body-centered lattice). Three-dimensional reconstructions from serial sections, optical diffractometry and comparison with crystal models were the techniques utilized. The significance of crystalline B-granules is discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00306971
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  • 3
    Digitale Medien
    Digitale Medien
    Ueber Oxycuminsäure (1880)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 13 (1880), S. 1660-1664 
    Details
    ISSN: 0365-9496
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/cber.188001302104
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  • 4
    Digitale Medien
    Digitale Medien
    Ueber Condensation tertiärer Basen mittelst Stickoxyd (1880)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 13 (1880), S. 2136-2141 
    Details
    ISSN: 0365-9496
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/cber.188001302207
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