ISSN:
1432-5233
Keywords:
Unclassifiable diabetes
;
Islet cell antibodies
;
C-peptide
;
Soluble CD8 antigen
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract To evaluate the predictive factors of insulin requirement in newly diagnosed patients with unclassifiable diabetes, 54 consecutive patients, aged less than 35 years, were prospectively followed for 3 years or more. At entry, haemoglobin HbAlc, basal and stimulated C-peptide concentrations, HLA phenotype, islet cell antibodies (ICA) status, and serum levels of soluble CD8 antigen (sCD8) were evaluated. After a median time of 9 (range 2–32) months, 31 patients (group 1) required insulin therapy, whereas 23 patients (group 2) remained non-insulin-requiring after 36 months. Group 1 patients were younger (P〈0.05) and had higher HbAlc and sCD8 serum levels (P〈0.001, respectively), a higher frequency of ICA positivity and of HLA DR3 and/or DR4 phenotype (P〈0.005 andP〈0.0001, respectively), and lower C-peptide concentrations (P〈0.005 andP〈0.0001, basal and stimulated, respectively) than group 2. The sensitivity, specificity, positive and negative predictive value, and overall accuracy for the subsequent insulin requirement were: sCD8 serum levels (〉737 U/ml), 100%, 65%, 79%, 100% and 85%, respectively; stimulated C-peptide (〈0.60 nmol/l), 71%, 96%, 96%, 74% and 81%, respectively; and ICA positivity (〉20 JDFU), 45%, 91%, 87%, 55% and 65%, respectively. Thus, higher sCD8 serum levels, low stimulated C-peptide concentrations and ICA positivity are the most powerful predictors of subsequent recourse to insulin therapy in young, newly detected patients with unclassifiable diabetes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02048547
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