ISSN:
1432-0584
Keywords:
Unstable hemoglobin
;
Hb Nottingham
;
Hemolytic anemia
;
Splenectomy
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary We report a fourth case of Hb Nottingham [α2β2 98 (FG5) Val→Gly] observed in an 8-year-old girl in the Czech Republic with clinical and laboratory symptoms of severe hemolytic anemia. The unstable hemoglobin probably represents a de novo mutation, since the parents of the patient and the two siblings do not exhibit any hematological abnormalities. Splenectomy had a beneficial effect on the degree of hemolysis, as well as on the Hb level.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01698489
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