ISSN:
1434-0879
Keywords:
Antiseptics
;
Urethral catheters
;
Urinary tract infections
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The activity of three antiseptic bladder washout solutions was examined in a physical model of the catheterized bladder. Tests were performed against cultures of four common urinary tract pathogens that had established themselves in the model and colonized the surfaces with biofilm. Double instillations of chlorhexidine (0.02% w/v) at 6-h intervals failed to eliminate Pseudomonas aeruginosa, Proteus mirabilis, and Providencia stuartii from the bladder model. Escherichia coli, however, was susceptible to a second instillation provided that it was performed within 12 h. Supplementing chlorhexidine with EDTA and TRIS potentiated its activity against E. coli. Mandelic acid (1.0% w/v) was the most effective of the agents, double instillations eliminating all but Pr. mirabilis infections.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00294496
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