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  • 1
    Electronic Resource
    Electronic Resource
    Influence of ethanol induction on the metabolic activation of genotoxic agents by isolated rat hepatocytes (1985)
    Springer
    Archives of toxicology 57 (1985), S. 217-221 
    Details
    ISSN: 1432-0738
    Keywords: Benzidine ; 2-Aminofluorene ; 2-Acetylaminofluorene ; Dimethylnitrosamine ; Diethylnitrosamine ; Isoniazid ; Cyclophosphamide ; Ethanol-induction ; Cytochrome P-450 ; N-acetylation ; Isolated rat hepatocytes ; Mutagenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of ethanol-feeding to rats, over a 6-week period, on the activation of genotoxic compounds of different chemical classes, requiring metabolic conversion to exert their mutagenic activity, were studied in isolated rat hepatocytes. The influence of such treatment on cytochrome P-450 content and N-acetylation in isolated hepatocytes was also investigated. Benzidine (BZ), dimethylnitrosamine (DMN), diethylnitrosamine (DEN), isoniazid (INH) and cyclophosphamide (CP) were more effectively activated to products mutagenic towards Salmonella typhimurium by hepatocytes from ethanol-pretreated rats than by hepatocytes from controls. The mutagenic potency of 2-aminofluorene (2-AF) and 2-acetylaminofluorene (2-AAF) was not influenced by ethanol pretreatment. Ethanol consumption was found to be associated with increased cytochrome P-450 content and enhanced N-acetylation in the isolated hepatocytes. Our results support the hypothesis that an alteration of the hepatic drug-metabolizing system may be responsible for the ethanol-induced increase in susceptibility to certain genotoxic compounds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00324780
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    1-Hydroxypyrene in human urine after exposure to coal tar and a coal tar derived product (1985)
    Springer
    International archives of occupational and environmental health 57 (1985), S. 47-55 
    Details
    ISSN: 1432-1246
    Keywords: Pyrene ; Urine ; Coal tar ; Eczema patients ; Workers ; Polycyclic aromatic hydrocarbons
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A method for isolating 1-hydroxypyrene from urine is described. The presence of 1-hydroxypyrene in urine was identified by fluorescence excitation and emission scanning after HPLC-separation. 1-Hydroxypyrene could be detected in the urine of rats following oral administration of as little as 0.5 μg pyrene. The dose-dependence of 1-hydroxypyrene in urine was evident after a wide range of pyrene dosing. After therapeutical coal tar treatment of dermatological patients the enhanced excretion of 1-hydroxypyrene was highly significant. Employees of a creosote impregnating plant showed an excretion pattern of 1-hydroxypyrene which could be related to their work. 1-Hydroxypyrene in urine of non-exposed people was very low, but detectable. It is suggested that the method reported is suitable for the assessment of uptake of man to pyrene, a compound that is commonly present in work environments which are associated with pollution of polycyclic aromatic hydrocarbons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00383545
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Urinary cyclophosphamide assay as a method for biological monitoring of occupational exposure to cyclophosphamide (1986)
    Springer
    International archives of occupational and environmental health 58 (1986), S. 151-155 
    Details
    ISSN: 1432-1246
    Keywords: Cyclophosphamide ; Urine ; Hospital workers ; Biological monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Urine of twenty hospital workers was monitored for the excretion of the cytostatic drug cyclophosphamide using GC-MSD. The drug was found to be present above the detection limit of 0.5 μg/24 h urine in five cases. A clear relationship between cyclophosphamide handling and the detectability of excretion existed. This method developed can be of use for biological monitoring studies directed toward the finding of exposure hazards.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00380766
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    Paper (German National Licenses)
    Fulltext
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