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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archives of gynecology and obstetrics 234 (1984), S. 181-188 
    ISSN: 1432-0711
    Keywords: Proteinases ; Proteinase inhibitor ; Uterus ; Carcinoma ; Leiomyoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The activities of an acid proteinase, of an alkaline proteinase, of a lysine aminopeptidase and of a proteinase B inhibitor were measured in benign and malignant tumors of the human uterus. In carcinomas of the corpus uteri the activity of the acid proteinase (cathepsin D) was increased compared to normal endometrium. This could probably be the result of cell destruction within the tumor. In leiomyomas of the uterus the activities of the alkaline proteinase, of the lysine aminopeptidase, and of the proteinase inhibitor were decreased compared to the normal myometrium. These results suggest that a decrease in the rate of degradation of myofibrillar proteins relative to the rate of protein synthesis may be responsible for the growth of myomas.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Archives of gynecology and obstetrics 222 (1977), S. 231-238 
    ISSN: 1432-0711
    Keywords: Uterus ; Involution ; Hypotrophy ; Hypoplasia ; Hyperinvolution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Beim postpartalen Rattenuterus wurden während 10 Tagen nach dem Wurf Uterusgewicht, lösliches Protein und DNS gemessen. Uterusgewicht und Proteingehalt des Gesamtuterus fielen nach einer Latenz von 48 Std in ähnlichem Verlauf auf 1/12 des Ausgangswertes ab, während der DNS-Gehalt sich nicht signifikant änderte. Der Anteil der Hypoplasie an der Gewichtsreduktion betrug maximal 20%, während mindestens 80% des Gewebeschwundes durch Hypotrophie zustande kamen. Die Proteinmenge pro Zellkern (mg Protein/mg DNS) fiel innerhalb von 10 Tagen um 85% ab. Bei nicht trächtigen Vergleichstieren lagen Uterusgewicht und Proteinmenge pro Zellkern über den entsprechenden Werten bei Tieren am 10. Tag post partum. Die Proteinkonzentration des Gewebes (mg Protein/g Feuchtgewicht) war dagegen niedriger. Diese Hyperinvolution am 10. Tag wird als Folge des gegenüber Normaltieren niedrigeren Östrogenspiegels der lactierenden Tiere erklärt.
    Notes: Summary In post partum rat uteri, the wet weight, the soluble protein and the DNA content were measured for ten days following delivery. After a lag period of 48 h, the weight and protein content of whole uteri decreased in parallel to one twelfth of the initial values. The DNA content did not change significantly. Hypoplasia contributed not more than 20% to the weight loss, so that at least 80% of the loss was due to hypotrophy. The protein content per cell nucleus (mg protein/mg DNA) decreased by 85% within 10 days. In non-pregnant control animals, uterus weight and protein content per cell nucleus were greater than those of animals measured on the tenth post partum day. In contrast, the protein concentration of the tissue (mg protein/g wet weight) was lower in the control group. It is suggested that this hyperinvolution is caused by the low estrogen levels of the lactating animals.
    Type of Medium: Electronic Resource
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