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Digitale Medien

Pharmacology of the isolated semicircular canal: Effect of GABA and picrotoxin (1984)

Guth, S. L. ; Norris, C. H.

Springer

Experimental brain research 56 (1984), S. 72-78

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Details

ISSN: 1432-1106

Schlagwort(e): Vestibular system ; Neurotransmitter ; GABA ; Picrotoxin ; Bullfrog

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary We have investigated the proposal that gamma aminobutyric acid (GABA) is the afferent transmitter in the vestibular system using the isolated posterior semicircular canal of the bullfrog (Rana catesbeiana). This was done by examining the effects of GABA and picrotoxin on the evoked response of neural units in the posterior ampullar nerve. GABA had no effect on evoked response up to 1mM, and inhibited the evoked response at 10mM. Picrotoxin, a GABA antagonist, had no effect on evoked response between 5 μM and 100 μM. These results indicate that GABA is not the afferent transmitter in the vestibular system.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00237443

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